STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR27Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G- protein coupled receptor; G protein-coupled receptors, Class A orphans (375 aa)    
Predicted Functional Partners:
GPR101
Probable G-protein coupled receptor 101; Orphan receptor; G protein-coupled receptors, Class A orphans
   
  
 0.721
GPR82
Probable G-protein coupled receptor 82; Orphan receptor; G protein-coupled receptors, Class A orphans
      
 0.674
EIF4E3
Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity)
   
  
 0.656
GPR162
Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans
   
  
 0.633
GPR63
Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans
   
  
 0.561
GPR1
G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1; G protein-coupled receptors, Class A orphans
      
 0.558
PROK2
Prokineticin-2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle; Endogenous ligands
   
  
 0.548
ARRB2
Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and rec [...]
    
 
 0.527
GPR25
Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans
   
  
 0.523
GPR62
Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans
   
  
 0.523
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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