node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | GPR27 | ENSP00000360268 | ENSP00000303149 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor. | 0.694 |
EIF4E3 | GPR27 | ENSP00000393324 | ENSP00000303149 | Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity). | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor. | 0.622 |
GNAS | GPR15 | ENSP00000360141 | ENSP00000284311 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | 0.499 |
GNAS | GPR150 | ENSP00000360141 | ENSP00000369344 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.621 |
GNAS | GPR176 | ENSP00000360141 | ENSP00000453076 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production. | 0.618 |
GNAS | GPR20 | ENSP00000360141 | ENSP00000366970 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. | 0.499 |
GNAS | GPR25 | ENSP00000360141 | ENSP00000301917 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | Probable G-protein coupled receptor 25; Orphan receptor. | 0.552 |
GNAS | GPR27 | ENSP00000360141 | ENSP00000303149 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor. | 0.557 |
GNAS | GPR45 | ENSP00000360141 | ENSP00000258456 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function. | 0.552 |
GNAS | GPR84 | ENSP00000360141 | ENSP00000450310 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. | 0.616 |
GPR15 | GNAS | ENSP00000284311 | ENSP00000360141 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | 0.499 |
GPR15 | GPR150 | ENSP00000284311 | ENSP00000369344 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.578 |
GPR15 | GPR176 | ENSP00000284311 | ENSP00000453076 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repress cAMP production. | 0.520 |
GPR15 | GPR20 | ENSP00000284311 | ENSP00000366970 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. | 0.483 |
GPR15 | GPR25 | ENSP00000284311 | ENSP00000301917 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 25; Orphan receptor. | 0.530 |
GPR15 | GPR27 | ENSP00000284311 | ENSP00000303149 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor. | 0.574 |
GPR15 | GPR45 | ENSP00000284311 | ENSP00000258456 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function. | 0.527 |
GPR15 | GPR84 | ENSP00000284311 | ENSP00000450310 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. | 0.511 |
GPR150 | GNAS | ENSP00000369344 | ENSP00000360141 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). | 0.621 |
GPR150 | GPR15 | ENSP00000369344 | ENSP00000284311 | Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family. | 0.578 |