node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MTHFSD | ZNF561 | ENSP00000354152 | ENSP00000303915 | Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing. | Zinc finger protein 561; May be involved in transcriptional regulation. | 0.401 |
SETD4 | ZNF561 | ENSP00000382163 | ENSP00000303915 | SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. | Zinc finger protein 561; May be involved in transcriptional regulation. | 0.488 |
TEX19 | ZNF561 | ENSP00000331500 | ENSP00000303915 | Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...] | Zinc finger protein 561; May be involved in transcriptional regulation. | 0.420 |
TRIM28 | ZNF561 | ENSP00000253024 | ENSP00000303915 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 561; May be involved in transcriptional regulation. | 0.692 |
TRIM28 | ZNF562 | ENSP00000253024 | ENSP00000410734 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.563 |
TRIM28 | ZNF616 | ENSP00000253024 | ENSP00000471000 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 616; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.616 |
ZNF561 | MTHFSD | ENSP00000303915 | ENSP00000354152 | Zinc finger protein 561; May be involved in transcriptional regulation. | Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing. | 0.401 |
ZNF561 | SETD4 | ENSP00000303915 | ENSP00000382163 | Zinc finger protein 561; May be involved in transcriptional regulation. | SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. | 0.488 |
ZNF561 | TEX19 | ENSP00000303915 | ENSP00000331500 | Zinc finger protein 561; May be involved in transcriptional regulation. | Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...] | 0.420 |
ZNF561 | TRIM28 | ENSP00000303915 | ENSP00000253024 | Zinc finger protein 561; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.692 |
ZNF561 | ZNF562 | ENSP00000303915 | ENSP00000410734 | Zinc finger protein 561; May be involved in transcriptional regulation. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.795 |
ZNF561 | ZNF616 | ENSP00000303915 | ENSP00000471000 | Zinc finger protein 561; May be involved in transcriptional regulation. | Zinc finger protein 616; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.459 |
ZNF562 | TRIM28 | ENSP00000410734 | ENSP00000253024 | Zinc finger protein 562; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.563 |
ZNF562 | ZNF561 | ENSP00000410734 | ENSP00000303915 | Zinc finger protein 562; May be involved in transcriptional regulation. | Zinc finger protein 561; May be involved in transcriptional regulation. | 0.795 |
ZNF616 | TRIM28 | ENSP00000471000 | ENSP00000253024 | Zinc finger protein 616; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.616 |
ZNF616 | ZNF561 | ENSP00000471000 | ENSP00000303915 | Zinc finger protein 616; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 561; May be involved in transcriptional regulation. | 0.459 |