LRRC28 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Knowledge-based Evidence

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP5B1	LRRC28	ENSP00000454303	ENSP00000304923	AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	0.496
CUL5	LRRC28	ENSP00000376808	ENSP00000304923	Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5- SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...]	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	0.567
FAM217B	LRRC28	ENSP00000351040	ENSP00000304923	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family.	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	0.491
HSPA8	HSPD1	ENSP00000437125	ENSP00000340019	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back- to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ri [...]	0.999
HSPA8	LRRC28	ENSP00000437125	ENSP00000304923	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	0.525
HSPD1	HSPA8	ENSP00000340019	ENSP00000437125	60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back- to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ri [...]	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.999
HSPD1	LRRC28	ENSP00000340019	ENSP00000304923	60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back- to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ri [...]	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	0.564
LRRC28	AP5B1	ENSP00000304923	ENSP00000454303	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.	0.496
LRRC28	CUL5	ENSP00000304923	ENSP00000376808	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5- SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulate [...]	0.567
LRRC28	FAM217B	ENSP00000304923	ENSP00000351040	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family.	0.491
LRRC28	HSPA8	ENSP00000304923	ENSP00000437125	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.525
LRRC28	HSPD1	ENSP00000304923	ENSP00000340019	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back- to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ri [...]	0.564
LRRC28	LUM	ENSP00000304923	ENSP00000266718	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.496
LRRC28	NFATC1	ENSP00000304923	ENSP00000389377	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).	0.512
LRRC28	NYX	ENSP00000304923	ENSP00000340328	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Nyctalopin.	0.627
LRRC28	PRELP	ENSP00000304923	ENSP00000343924	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.509
LRRC28	SUPT3H	ENSP00000304923	ENSP00000360515	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	Transcription initiation protein SPT3 homolog; Probable transcriptional activator.	0.499
LUM	LRRC28	ENSP00000266718	ENSP00000304923	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.	0.496
LUM	NYX	ENSP00000266718	ENSP00000340328	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Nyctalopin.	0.429
LUM	PRELP	ENSP00000266718	ENSP00000343924	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.786