node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSH1 | CSH2 | ENSP00000316416 | ENSP00000376623 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.998 |
CSH1 | PAPPA | ENSP00000316416 | ENSP00000330658 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. | 0.592 |
CSH1 | PSG1 | ENSP00000316416 | ENSP00000308970 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family. | 0.774 |
CSH1 | PSG3 | ENSP00000316416 | ENSP00000332215 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.788 |
CSH1 | PSG4 | ENSP00000316416 | ENSP00000384770 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 4. | 0.772 |
CSH1 | PSG6 | ENSP00000316416 | ENSP00000292125 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 6. | 0.788 |
CSH1 | PSG8 | ENSP00000316416 | ENSP00000305005 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 8. | 0.767 |
CSH2 | CSH1 | ENSP00000376623 | ENSP00000316416 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.998 |
CSH2 | PAPPA | ENSP00000376623 | ENSP00000330658 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. | 0.590 |
CSH2 | PSG1 | ENSP00000376623 | ENSP00000308970 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family. | 0.774 |
CSH2 | PSG3 | ENSP00000376623 | ENSP00000332215 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.783 |
CSH2 | PSG4 | ENSP00000376623 | ENSP00000384770 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 4. | 0.771 |
CSH2 | PSG6 | ENSP00000376623 | ENSP00000292125 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 6. | 0.784 |
CSH2 | PSG8 | ENSP00000376623 | ENSP00000305005 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 8. | 0.764 |
MEGF8 | PSG1 | ENSP00000251268 | ENSP00000308970 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family. | 0.693 |
MEGF8 | PSG3 | ENSP00000251268 | ENSP00000332215 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.628 |
MEGF8 | PSG8 | ENSP00000251268 | ENSP00000305005 | Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling. | Pregnancy specific beta-1-glycoprotein 8. | 0.635 |
PAPPA | CSH1 | ENSP00000330658 | ENSP00000316416 | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.592 |
PAPPA | CSH2 | ENSP00000330658 | ENSP00000376623 | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.590 |
PAPPA | PSG1 | ENSP00000330658 | ENSP00000308970 | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family. | 0.660 |