node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATIC | CNNM3 | ENSP00000236959 | ENSP00000305449 | Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | 0.633 |
ATIC | GMPS | ENSP00000236959 | ENSP00000419851 | Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.921 |
ATIC | NT5E | ENSP00000236959 | ENSP00000257770 | Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 5'-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. | 0.937 |
CBS | CBSL | ENSP00000381231 | ENSP00000485527 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | Cystathionine beta-synthase like. | 0.900 |
CBS | CNNM3 | ENSP00000381231 | ENSP00000305449 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | 0.836 |
CBS | GMPS | ENSP00000381231 | ENSP00000419851 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.526 |
CBS | SLC41A1 | ENSP00000381231 | ENSP00000356105 | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.426 |
CBSL | CBS | ENSP00000485527 | ENSP00000381231 | Cystathionine beta-synthase like. | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | 0.900 |
CBSL | CNNM3 | ENSP00000485527 | ENSP00000305449 | Cystathionine beta-synthase like. | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | 0.855 |
CBSL | GMPS | ENSP00000485527 | ENSP00000419851 | Cystathionine beta-synthase like. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.513 |
CBSL | SLC41A1 | ENSP00000485527 | ENSP00000356105 | Cystathionine beta-synthase like. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.425 |
CNNM3 | ATIC | ENSP00000305449 | ENSP00000236959 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.633 |
CNNM3 | CBS | ENSP00000305449 | ENSP00000381231 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | 0.836 |
CNNM3 | CBSL | ENSP00000305449 | ENSP00000485527 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Cystathionine beta-synthase like. | 0.855 |
CNNM3 | GMPS | ENSP00000305449 | ENSP00000419851 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.701 |
CNNM3 | NIPAL3 | ENSP00000305449 | ENSP00000363520 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | NIPA-like protein 3; NIPA like domain containing 3. | 0.606 |
CNNM3 | NT5E | ENSP00000305449 | ENSP00000257770 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | 5'-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. | 0.615 |
CNNM3 | PTP4A1 | ENSP00000305449 | ENSP00000497588 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.798 |
CNNM3 | PTP4A2 | ENSP00000305449 | ENSP00000493688 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.998 |
CNNM3 | PTP4A3 | ENSP00000305449 | ENSP00000428976 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 3; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. | 0.945 |