node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG9A | ATG9B | ENSP00000386710 | ENSP00000491504 | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. Belongs to the ATG9 family. | Autophagy-related protein 9B; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity); Belongs to the ATG9 family. | 0.913 |
ATG9A | TMEM208 | ENSP00000386710 | ENSP00000305892 | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. Belongs to the ATG9 family. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.840 |
ATG9B | ATG9A | ENSP00000491504 | ENSP00000386710 | Autophagy-related protein 9B; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity); Belongs to the ATG9 family. | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. Belongs to the ATG9 family. | 0.913 |
ATG9B | TMEM208 | ENSP00000491504 | ENSP00000305892 | Autophagy-related protein 9B; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity); Belongs to the ATG9 family. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.840 |
FBXL8 | TMEM208 | ENSP00000258200 | ENSP00000305892 | F-box/LRR-repeat protein 8; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.616 |
GET1 | GET3 | ENSP00000496813 | ENSP00000466379 | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.999 |
GET1 | TMEM208 | ENSP00000496813 | ENSP00000305892 | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.605 |
GET3 | GET1 | ENSP00000466379 | ENSP00000496813 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family. | 0.999 |
GET3 | TMEM208 | ENSP00000466379 | ENSP00000305892 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.627 |
RABAC1 | RTN4 | ENSP00000222008 | ENSP00000337838 | Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. Belongs to the PRA1 family. | Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vas [...] | 0.620 |
RABAC1 | TMEM208 | ENSP00000222008 | ENSP00000305892 | Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. Belongs to the PRA1 family. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.541 |
RTN4 | RABAC1 | ENSP00000337838 | ENSP00000222008 | Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vas [...] | Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. Belongs to the PRA1 family. | 0.620 |
RTN4 | TMEM208 | ENSP00000337838 | ENSP00000305892 | Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vas [...] | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.722 |
SLC35B1 | TMEM208 | ENSP00000497423 | ENSP00000305892 | Solute carrier family 35 member B1; Probable sugar transporter; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.606 |
SWI5 | TMEM208 | ENSP00000316609 | ENSP00000305892 | DNA repair protein SWI5 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | 0.960 |
TMEM208 | ATG9A | ENSP00000305892 | ENSP00000386710 | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. Belongs to the ATG9 family. | 0.840 |
TMEM208 | ATG9B | ENSP00000305892 | ENSP00000491504 | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | Autophagy-related protein 9B; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity); Belongs to the ATG9 family. | 0.840 |
TMEM208 | FBXL8 | ENSP00000305892 | ENSP00000258200 | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | F-box/LRR-repeat protein 8; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.616 |
TMEM208 | GET1 | ENSP00000305892 | ENSP00000496813 | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family. | 0.605 |
TMEM208 | GET3 | ENSP00000305892 | ENSP00000466379 | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.627 |