node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IVL | LOR | ENSP00000357753 | ENSP00000357731 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Loricrin; Major keratinocyte cell envelope protein. | 0.999 |
IVL | SPRR1A | ENSP00000357753 | ENSP00000357751 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.963 |
IVL | SPRR1B | ENSP00000357753 | ENSP00000306461 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage; Belongs to the cornifin (SPRR) family. | 0.967 |
IVL | SPRR2A | ENSP00000357753 | ENSP00000376423 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Small proline rich protein 2A. | 0.776 |
IVL | SPRR2B | ENSP00000357753 | ENSP00000357744 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Small proline-rich protein 2A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Belongs to the cornifin (SPRR) family. | 0.754 |
IVL | SPRR2D | ENSP00000357753 | ENSP00000357746 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.709 |
IVL | SPRR2E | ENSP00000357753 | ENSP00000357740 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Small proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.666 |
IVL | SPRR2F | ENSP00000357753 | ENSP00000418193 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Small proline-rich protein 2F; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). | 0.611 |
IVL | SPRR2G | ENSP00000357753 | ENSP00000357737 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). | 0.662 |
IVL | TGM1 | ENSP00000357753 | ENSP00000206765 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.989 |
LOR | IVL | ENSP00000357731 | ENSP00000357753 | Loricrin; Major keratinocyte cell envelope protein. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | 0.999 |
LOR | SPRR1A | ENSP00000357731 | ENSP00000357751 | Loricrin; Major keratinocyte cell envelope protein. | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.917 |
LOR | SPRR1B | ENSP00000357731 | ENSP00000306461 | Loricrin; Major keratinocyte cell envelope protein. | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage; Belongs to the cornifin (SPRR) family. | 0.928 |
LOR | SPRR2A | ENSP00000357731 | ENSP00000376423 | Loricrin; Major keratinocyte cell envelope protein. | Small proline rich protein 2A. | 0.747 |
LOR | SPRR2B | ENSP00000357731 | ENSP00000357744 | Loricrin; Major keratinocyte cell envelope protein. | Small proline-rich protein 2A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Belongs to the cornifin (SPRR) family. | 0.765 |
LOR | SPRR2D | ENSP00000357731 | ENSP00000357746 | Loricrin; Major keratinocyte cell envelope protein. | Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.695 |
LOR | SPRR2E | ENSP00000357731 | ENSP00000357740 | Loricrin; Major keratinocyte cell envelope protein. | Small proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. | 0.654 |
LOR | SPRR2F | ENSP00000357731 | ENSP00000418193 | Loricrin; Major keratinocyte cell envelope protein. | Small proline-rich protein 2F; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). | 0.565 |
LOR | SPRR2G | ENSP00000357731 | ENSP00000357737 | Loricrin; Major keratinocyte cell envelope protein. | Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). | 0.763 |
LOR | TGM1 | ENSP00000357731 | ENSP00000206765 | Loricrin; Major keratinocyte cell envelope protein. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.933 |