node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP11 | GPC5 | ENSP00000025301 | ENSP00000366267 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.608 |
AKAP11 | IRX1 | ENSP00000025301 | ENSP00000305244 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | 0.664 |
AKAP11 | IRX2 | ENSP00000025301 | ENSP00000307006 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | Iroquois-class homeodomain protein IRX-2; Iroquois homeobox 2. | 0.697 |
AKAP11 | IRX3 | ENSP00000025301 | ENSP00000331608 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | 0.731 |
AKAP11 | POSTN | ENSP00000025301 | ENSP00000369071 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | Periostin; Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). | 0.553 |
C5orf38 | IRX2 | ENSP00000334267 | ENSP00000307006 | Protein CEI; Chromosome 5 open reading frame 38. | Iroquois-class homeodomain protein IRX-2; Iroquois homeobox 2. | 0.562 |
GPC5 | AKAP11 | ENSP00000366267 | ENSP00000025301 | Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | 0.608 |
GPC5 | IRX1 | ENSP00000366267 | ENSP00000305244 | Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | 0.510 |
GPC5 | IRX2 | ENSP00000366267 | ENSP00000307006 | Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Iroquois-class homeodomain protein IRX-2; Iroquois homeobox 2. | 0.557 |
GPC5 | IRX3 | ENSP00000366267 | ENSP00000331608 | Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | 0.551 |
GPC5 | POSTN | ENSP00000366267 | ENSP00000369071 | Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Periostin; Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). | 0.449 |
HHEX | IRX1 | ENSP00000282728 | ENSP00000305244 | Hematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | 0.548 |
HHEX | IRX2 | ENSP00000282728 | ENSP00000307006 | Hematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). | Iroquois-class homeodomain protein IRX-2; Iroquois homeobox 2. | 0.623 |
HHEX | IRX3 | ENSP00000282728 | ENSP00000331608 | Hematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | 0.590 |
HOXB8 | IRX2 | ENSP00000239144 | ENSP00000307006 | Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Iroquois-class homeodomain protein IRX-2; Iroquois homeobox 2. | 0.605 |
IRX1 | AKAP11 | ENSP00000305244 | ENSP00000025301 | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family. | 0.664 |
IRX1 | GPC5 | ENSP00000305244 | ENSP00000366267 | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.510 |
IRX1 | HHEX | ENSP00000305244 | ENSP00000282728 | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | Hematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). | 0.548 |
IRX1 | IRX2 | ENSP00000305244 | ENSP00000307006 | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | Iroquois-class homeodomain protein IRX-2; Iroquois homeobox 2. | 0.596 |
IRX1 | IRX3 | ENSP00000305244 | ENSP00000331608 | Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1. | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | 0.561 |