STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C8orf74Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74. (294 aa)    
Predicted Functional Partners:
MORN2
MORN repeat-containing protein 2; Might have a role in spermatogenesis.
    
   0.603
NKX2-4
Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family.
   
  
 0.549
FGFR2
Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell p [...]
    
   0.520
SATL1
Spermidine/spermine N1-acetyl transferase like 1.
      
 0.479
KIZ
Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family.
      
 0.472
C1orf141
Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141.
   
  
 0.435
XKR6
XK-related protein 6; XK related 6; Belongs to the XK family.
      
 0.416
PRSS55
Serine protease 55; Probable serine protease.
   
  
 0.403
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.