node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3 | SHE | ENSP00000245907 | ENSP00000307369 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.458 |
DRC7 | SHE | ENSP00000353942 | ENSP00000307369 | Dynein regulatory complex subunit 7; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.438 |
EMCN | SHE | ENSP00000296420 | ENSP00000307369 | Endomucin; Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.494 |
EPHX2 | SHE | ENSP00000430269 | ENSP00000307369 | Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10- phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10- phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z- enoic acid and 12-phospho [...] | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.434 |
SHC1 | SHD | ENSP00000401303 | ENSP00000446058 | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, [...] | SH2 domain-containing adapter protein D; May function as an adapter protein. | 0.433 |
SHC1 | SHE | ENSP00000401303 | ENSP00000307369 | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, [...] | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.561 |
SHD | SHC1 | ENSP00000446058 | ENSP00000401303 | SH2 domain-containing adapter protein D; May function as an adapter protein. | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, [...] | 0.433 |
SHD | SHE | ENSP00000446058 | ENSP00000307369 | SH2 domain-containing adapter protein D; May function as an adapter protein. | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.443 |
SHE | C3 | ENSP00000307369 | ENSP00000245907 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.458 |
SHE | DRC7 | ENSP00000307369 | ENSP00000353942 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | Dynein regulatory complex subunit 7; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. | 0.438 |
SHE | EMCN | ENSP00000307369 | ENSP00000296420 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | Endomucin; Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. | 0.494 |
SHE | EPHX2 | ENSP00000307369 | ENSP00000430269 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10- phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10- phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z- enoic acid and 12-phospho [...] | 0.434 |
SHE | SHC1 | ENSP00000307369 | ENSP00000401303 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, [...] | 0.561 |
SHE | SHD | ENSP00000307369 | ENSP00000446058 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | SH2 domain-containing adapter protein D; May function as an adapter protein. | 0.443 |
SHE | TDRD10 | ENSP00000307369 | ENSP00000357465 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | Tudor domain containing 10. | 0.641 |
SHE | TMEM100 | ENSP00000307369 | ENSP00000465638 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open [...] | 0.618 |
SHE | ZNF180 | ENSP00000307369 | ENSP00000221327 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | Zinc finger protein 180; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.506 |
TDRD10 | SHE | ENSP00000357465 | ENSP00000307369 | Tudor domain containing 10. | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.641 |
TMEM100 | SHE | ENSP00000465638 | ENSP00000307369 | Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open [...] | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.618 |
ZNF180 | SHE | ENSP00000221327 | ENSP00000307369 | Zinc finger protein 180; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | SH2 domain-containing adapter protein E; Src homology 2 domain containing E. | 0.506 |