node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSM2A | SLC22A25 | ENSP00000459451 | ENSP00000307443 | Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family. | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.633 |
SLC16A9 | SLC22A23 | ENSP00000378757 | ENSP00000385028 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. | Solute carrier family 22 member 23. | 0.446 |
SLC16A9 | SLC22A25 | ENSP00000378757 | ENSP00000307443 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.428 |
SLC22A15 | SLC22A17 | ENSP00000358515 | ENSP00000380437 | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | 0.476 |
SLC22A15 | SLC22A18 | ENSP00000358515 | ENSP00000369948 | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.644 |
SLC22A15 | SLC22A23 | ENSP00000358515 | ENSP00000385028 | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. | Solute carrier family 22 member 23. | 0.498 |
SLC22A15 | SLC22A25 | ENSP00000358515 | ENSP00000307443 | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.502 |
SLC22A17 | SLC22A15 | ENSP00000380437 | ENSP00000358515 | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. | 0.476 |
SLC22A17 | SLC22A18 | ENSP00000380437 | ENSP00000369948 | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.582 |
SLC22A17 | SLC22A25 | ENSP00000380437 | ENSP00000307443 | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.461 |
SLC22A18 | SLC22A15 | ENSP00000369948 | ENSP00000358515 | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. | 0.644 |
SLC22A18 | SLC22A17 | ENSP00000369948 | ENSP00000380437 | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | 0.582 |
SLC22A18 | SLC22A23 | ENSP00000369948 | ENSP00000385028 | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Solute carrier family 22 member 23. | 0.653 |
SLC22A18 | SLC22A25 | ENSP00000369948 | ENSP00000307443 | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.641 |
SLC22A18 | SLC22A31 | ENSP00000369948 | ENSP00000474621 | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.675 |
SLC22A23 | SLC16A9 | ENSP00000385028 | ENSP00000378757 | Solute carrier family 22 member 23. | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. | 0.446 |
SLC22A23 | SLC22A15 | ENSP00000385028 | ENSP00000358515 | Solute carrier family 22 member 23. | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. | 0.498 |
SLC22A23 | SLC22A18 | ENSP00000385028 | ENSP00000369948 | Solute carrier family 22 member 23. | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.653 |
SLC22A23 | SLC22A25 | ENSP00000385028 | ENSP00000307443 | Solute carrier family 22 member 23. | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.502 |
SLC22A25 | ACSM2A | ENSP00000307443 | ENSP00000459451 | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family. | 0.633 |