| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRNN | TMPRSS11E | ENSP00000271835 | ENSP00000307519 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | 0.423 |
| SERPINA5 | SERPINE1 | ENSP00000333203 | ENSP00000223095 | Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It [...] | 0.812 |
| SERPINA5 | TMPRSS11E | ENSP00000333203 | ENSP00000307519 | Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | 0.843 |
| SERPINE1 | SERPINA5 | ENSP00000223095 | ENSP00000333203 | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It [...] | Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] | 0.812 |
| SERPINE1 | TMPRSS11E | ENSP00000223095 | ENSP00000307519 | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It [...] | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | 0.651 |
| TMPRSS11E | CRNN | ENSP00000307519 | ENSP00000271835 | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.423 |
| TMPRSS11E | SERPINA5 | ENSP00000307519 | ENSP00000333203 | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] | 0.843 |
| TMPRSS11E | SERPINE1 | ENSP00000307519 | ENSP00000223095 | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It [...] | 0.651 |
| TMPRSS11E | TMPRSS4 | ENSP00000307519 | ENSP00000416037 | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity). | 0.484 |
| TMPRSS4 | TMPRSS11E | ENSP00000416037 | ENSP00000307519 | Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity). | Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. | 0.484 |
