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TMPRSS11E protein (human) - STRING interaction network
"TMPRSS11E" - Transmembrane protease serine 11E in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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TMPRSS11ETransmembrane protease serine 11E; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position (423 aa)    
Predicted Functional Partners:
SERPINA5
Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] (406 aa)
       
 
  0.853
SERPINE1
Plasminogen activator inhibitor 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis; Serpin peptidase inhibitors (402 aa)
       
 
  0.689
STEAP4
Metalloreductase STEAP4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin- resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation; STEAP family (459 aa)
           
  0.610
MUC20
Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression; Mucins (709 aa)
           
  0.584
PCDH1
Protocadherin-1; May be involved in cell-cell interaction processes and in cell adhesion; Non-clustered protocadherins (1237 aa)
           
  0.583
MUC15
Mucin-15; May play a role in the cell adhesion to the extracellular matrix; Mucins (361 aa)
           
  0.581
OR5M3
Olfactory receptor 5M3; Odorant receptor; Olfactory receptors, family 5 (307 aa)
           
  0.536
SPINT1
Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) (529 aa)
     
 
  0.476
ANO1
Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development; Belongs to the anoctamin family (986 aa)
           
  0.459
CCPG1
Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation; Belongs to the CCPG1 family (807 aa)
           
  0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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