node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN1L | ZBTB5 | ENSP00000415822 | ENSP00000307604 | Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.439 |
BCOR | ZBTB5 | ENSP00000367705 | ENSP00000307604 | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA- binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' ( [...] | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.439 |
DCX | ZBTB5 | ENSP00000490614 | ENSP00000307604 | Neuronal migration protein doublecortin; Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.423 |
KBTBD3 | ZBTB5 | ENSP00000432163 | ENSP00000307604 | Kelch repeat and BTB domain containing 3. | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.426 |
MRPS31 | ZBTB5 | ENSP00000315397 | ENSP00000307604 | Mitochondrial ribosomal protein S31. | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.407 |
STPG4 | ZBTB5 | ENSP00000408527 | ENSP00000307604 | Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.418 |
TBC1D22B | ZBTB5 | ENSP00000362590 | ENSP00000307604 | TBC1 domain family member 22B; May act as a GTPase-activating protein for Rab family protein(s). | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.442 |
TP53 | ZBTB5 | ENSP00000269305 | ENSP00000307604 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.490 |
ZBTB5 | ATXN1L | ENSP00000307604 | ENSP00000415822 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). | 0.439 |
ZBTB5 | BCOR | ENSP00000307604 | ENSP00000367705 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA- binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' ( [...] | 0.439 |
ZBTB5 | DCX | ENSP00000307604 | ENSP00000490614 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Neuronal migration protein doublecortin; Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. | 0.423 |
ZBTB5 | KBTBD3 | ENSP00000307604 | ENSP00000432163 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Kelch repeat and BTB domain containing 3. | 0.426 |
ZBTB5 | MRPS31 | ENSP00000307604 | ENSP00000315397 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Mitochondrial ribosomal protein S31. | 0.407 |
ZBTB5 | STPG4 | ENSP00000307604 | ENSP00000408527 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). | 0.418 |
ZBTB5 | TBC1D22B | ENSP00000307604 | ENSP00000362590 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | TBC1 domain family member 22B; May act as a GTPase-activating protein for Rab family protein(s). | 0.442 |
ZBTB5 | TP53 | ENSP00000307604 | ENSP00000269305 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.490 |
ZBTB5 | ZBTB7B | ENSP00000307604 | ENSP00000406286 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Zinc finger and BTB domain-containing protein 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I mo [...] | 0.417 |
ZBTB5 | ZNF639 | ENSP00000307604 | ENSP00000325634 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.422 |
ZBTB7B | ZBTB5 | ENSP00000406286 | ENSP00000307604 | Zinc finger and BTB domain-containing protein 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I mo [...] | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.417 |
ZNF639 | ZBTB5 | ENSP00000325634 | ENSP00000307604 | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation. | 0.422 |