TTC36 protein (human) - STRING interaction network

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Score

TTC36

Tetratricopeptide repeat domain 36. (189 aa)

Predicted Functional Partners:

HPD

0.686

HGD

0.640

FAH

0.577

HSPA4

0.508

STK33

0.473

RNF138

0.454

TMEM74B

0.432

SRCIN1

0.422

GCC2

0.418

TTC38

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAH	HGD	ENSP00000385080	ENSP00000283871	Fumarylacetoacetase; Fumarylacetoacetate hydrolase.	Homogentisate 1,2-dioxygenase.	0.945
FAH	HPD	ENSP00000385080	ENSP00000289004	Fumarylacetoacetase; Fumarylacetoacetate hydrolase.	4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.	0.993
FAH	TTC36	ENSP00000385080	ENSP00000307640	Fumarylacetoacetase; Fumarylacetoacetate hydrolase.	Tetratricopeptide repeat domain 36.	0.577
GCC2	SRCIN1	ENSP00000307939	ENSP00000484715	GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2.	SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.	0.415
GCC2	TTC36	ENSP00000307939	ENSP00000307640	GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2.	Tetratricopeptide repeat domain 36.	0.418
HGD	FAH	ENSP00000283871	ENSP00000385080	Homogentisate 1,2-dioxygenase.	Fumarylacetoacetase; Fumarylacetoacetate hydrolase.	0.945
HGD	HPD	ENSP00000283871	ENSP00000289004	Homogentisate 1,2-dioxygenase.	4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.	0.999
HGD	TTC36	ENSP00000283871	ENSP00000307640	Homogentisate 1,2-dioxygenase.	Tetratricopeptide repeat domain 36.	0.640
HPD	FAH	ENSP00000289004	ENSP00000385080	4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.	Fumarylacetoacetase; Fumarylacetoacetate hydrolase.	0.993
HPD	HGD	ENSP00000289004	ENSP00000283871	4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.	Homogentisate 1,2-dioxygenase.	0.999
HPD	TTC36	ENSP00000289004	ENSP00000307640	4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.	Tetratricopeptide repeat domain 36.	0.686
HSPA4	TTC36	ENSP00000302961	ENSP00000307640	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Tetratricopeptide repeat domain 36.	0.508
RNF138	TTC36	ENSP00000261593	ENSP00000307640	E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex [...]	Tetratricopeptide repeat domain 36.	0.454
SRCIN1	GCC2	ENSP00000484715	ENSP00000307939	SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.	GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2.	0.415
SRCIN1	TTC36	ENSP00000484715	ENSP00000307640	SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.	Tetratricopeptide repeat domain 36.	0.422
STK33	TTC36	ENSP00000416750	ENSP00000307640	Serine/threonine-protein kinase 33; Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	Tetratricopeptide repeat domain 36.	0.473
TMEM74B	TTC36	ENSP00000371318	ENSP00000307640	Transmembrane protein 74B.	Tetratricopeptide repeat domain 36.	0.432
TTC36	FAH	ENSP00000307640	ENSP00000385080	Tetratricopeptide repeat domain 36.	Fumarylacetoacetase; Fumarylacetoacetate hydrolase.	0.577
TTC36	GCC2	ENSP00000307640	ENSP00000307939	Tetratricopeptide repeat domain 36.	GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2.	0.418
TTC36	HGD	ENSP00000307640	ENSP00000283871	Tetratricopeptide repeat domain 36.	Homogentisate 1,2-dioxygenase.	0.640