STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADGRF3Adhesion G-protein coupled receptor F3; Orphan receptor. (1079 aa)    
Predicted Functional Partners:
ADGRA1
Adhesion G protein-coupled receptor A1; Orphan receptor.
   
 
 0.602
CD164L2
CD164 molecule like 2; Belongs to the CD164 family.
      
 0.501
OR51T1
Olfactory receptor 51T1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.462
OR10H3
Olfactory receptor 10H3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.446
OR1N2
Olfactory receptor 1N2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.435
ADGRA3
Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
    
 
0.434
MEP1B
Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
   
  
 0.427
OR52N5
Olfactory receptor 52N5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.418
OR6N1
Olfactory receptor 6N1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.418
OR6X1
Olfactory receptor 6X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.400
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.