FAM174A protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCZ1	FAM174A	ENSP00000325681	ENSP00000307954	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	Membrane protein FAM174A; Family with sequence similarity 174 member A.	0.541
CDC123	COQ5	ENSP00000281141	ENSP00000288532	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2); Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.	0.476
CDC123	FAM174A	ENSP00000281141	ENSP00000307954	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	Membrane protein FAM174A; Family with sequence similarity 174 member A.	0.466
CDC123	GAK	ENSP00000281141	ENSP00000314499	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.	0.458
COQ5	CDC123	ENSP00000288532	ENSP00000281141	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2); Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.476
COQ5	FAM174A	ENSP00000288532	ENSP00000307954	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2); Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.	Membrane protein FAM174A; Family with sequence similarity 174 member A.	0.538
FAM174A	CCZ1	ENSP00000307954	ENSP00000325681	Membrane protein FAM174A; Family with sequence similarity 174 member A.	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	0.541
FAM174A	CDC123	ENSP00000307954	ENSP00000281141	Membrane protein FAM174A; Family with sequence similarity 174 member A.	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.466
FAM174A	COQ5	ENSP00000307954	ENSP00000288532	Membrane protein FAM174A; Family with sequence similarity 174 member A.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2); Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.	0.538
FAM174A	GAK	ENSP00000307954	ENSP00000314499	Membrane protein FAM174A; Family with sequence similarity 174 member A.	Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.	0.470
FAM174A	PEX19	ENSP00000307954	ENSP00000357051	Membrane protein FAM174A; Family with sequence similarity 174 member A.	Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.	0.650
FAM174A	RENBP	ENSP00000307954	ENSP00000377303	Membrane protein FAM174A; Family with sequence similarity 174 member A.	N-acylglucosamine 2-epimerase; Catalyzes the interconversion of N-acetylglucosamine to N- acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.	0.464
FAM174A	SLC39A11	ENSP00000307954	ENSP00000445829	Membrane protein FAM174A; Family with sequence similarity 174 member A.	Zinc transporter ZIP11; Functions as a cellular zinc transporter.	0.548
FAM174A	TMEM168	ENSP00000307954	ENSP00000323068	Membrane protein FAM174A; Family with sequence similarity 174 member A.	Transmembrane protein 168; Belongs to the TMEM168 family.	0.816
FAM174A	UAP1L1	ENSP00000307954	ENSP00000386935	Membrane protein FAM174A; Family with sequence similarity 174 member A.	UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1.	0.488
FAM174A	UHRF1BP1L	ENSP00000307954	ENSP00000279907	Membrane protein FAM174A; Family with sequence similarity 174 member A.	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like.	0.531
GAK	CDC123	ENSP00000314499	ENSP00000281141	Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.458
GAK	FAM174A	ENSP00000314499	ENSP00000307954	Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.	Membrane protein FAM174A; Family with sequence similarity 174 member A.	0.470
PEX19	FAM174A	ENSP00000357051	ENSP00000307954	Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.	Membrane protein FAM174A; Family with sequence similarity 174 member A.	0.650
RENBP	FAM174A	ENSP00000377303	ENSP00000307954	N-acylglucosamine 2-epimerase; Catalyzes the interconversion of N-acetylglucosamine to N- acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.	Membrane protein FAM174A; Family with sequence similarity 174 member A.	0.464