| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCD1 | IQCF1 | ENSP00000218104 | ENSP00000307958 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | 0.534 |
| ANKRD9 | IQCF1 | ENSP00000286918 | ENSP00000307958 | Ankyrin repeat domain 9. | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | 0.491 |
| ANKRD9 | TSSK6 | ENSP00000286918 | ENSP00000466477 | Ankyrin repeat domain 9. | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | 0.427 |
| CCDC83 | IQCF1 | ENSP00000280245 | ENSP00000307958 | Coiled-coil domain containing 83. | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | 0.585 |
| CCDC83 | KLHL10 | ENSP00000280245 | ENSP00000293303 | Coiled-coil domain containing 83. | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. | 0.493 |
| FAR2 | IQCF1 | ENSP00000443291 | ENSP00000307958 | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | 0.866 |
| IQCF1 | ABCD1 | ENSP00000307958 | ENSP00000218104 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid [...] | 0.534 |
| IQCF1 | ANKRD9 | ENSP00000307958 | ENSP00000286918 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Ankyrin repeat domain 9. | 0.491 |
| IQCF1 | CCDC83 | ENSP00000307958 | ENSP00000280245 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Coiled-coil domain containing 83. | 0.585 |
| IQCF1 | FAR2 | ENSP00000307958 | ENSP00000443291 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | 0.866 |
| IQCF1 | KLHL10 | ENSP00000307958 | ENSP00000293303 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. | 0.497 |
| IQCF1 | MUL1 | ENSP00000307958 | ENSP00000264198 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the con [...] | 0.795 |
| IQCF1 | PACS1 | ENSP00000307958 | ENSP00000316454 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans- Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster- containing cytoplasmic domain of these molecules with the adapter- protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN; Belongs to the PACS family. | 0.532 |
| IQCF1 | TBC1D21 | ENSP00000307958 | ENSP00000300504 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.523 |
| IQCF1 | TNP2 | ENSP00000307958 | ENSP00000325738 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.484 |
| IQCF1 | TSSK6 | ENSP00000307958 | ENSP00000466477 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | 0.538 |
| KLHL10 | CCDC83 | ENSP00000293303 | ENSP00000280245 | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. | Coiled-coil domain containing 83. | 0.493 |
| KLHL10 | IQCF1 | ENSP00000293303 | ENSP00000307958 | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | 0.497 |
| KLHL10 | TNP2 | ENSP00000293303 | ENSP00000325738 | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.436 |
| KLHL10 | TSSK6 | ENSP00000293303 | ENSP00000466477 | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | 0.469 |
