node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BANP | ZNF471 | ENSP00000376902 | ENSP00000309161 | Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity); Belongs to the BANP/SMAR1 family. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.472 |
CFAP69 | ZNF471 | ENSP00000373948 | ENSP00000309161 | Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.422 |
COG7 | ZNF471 | ENSP00000305442 | ENSP00000309161 | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.452 |
FAM228B | ZNF471 | ENSP00000482482 | ENSP00000309161 | Protein FAM228B; Family with sequence similarity 228 member B; Belongs to the FAM228 family. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.478 |
KIAA1755 | ZNF471 | ENSP00000279024 | ENSP00000309161 | Uncharacterized protein KIAA1755; KIAA1755. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.450 |
MIS18A | ZNF471 | ENSP00000290130 | ENSP00000309161 | Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.457 |
SLFN12 | ZNF471 | ENSP00000378063 | ENSP00000309161 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.458 |
THOC5 | ZNF471 | ENSP00000420306 | ENSP00000309161 | THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essentia [...] | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.433 |
TRIM28 | ZNF135 | ENSP00000253024 | ENSP00000441410 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 135; Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |
TRIM28 | ZNF471 | ENSP00000253024 | ENSP00000309161 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.669 |
ZNF135 | TRIM28 | ENSP00000441410 | ENSP00000253024 | Zinc finger protein 135; Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.522 |
ZNF135 | ZNF471 | ENSP00000441410 | ENSP00000309161 | Zinc finger protein 135; Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.419 |
ZNF471 | BANP | ENSP00000309161 | ENSP00000376902 | Zinc finger protein 471; May be involved in transcriptional regulation. | Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity); Belongs to the BANP/SMAR1 family. | 0.472 |
ZNF471 | CFAP69 | ENSP00000309161 | ENSP00000373948 | Zinc finger protein 471; May be involved in transcriptional regulation. | Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability. | 0.422 |
ZNF471 | COG7 | ENSP00000309161 | ENSP00000305442 | Zinc finger protein 471; May be involved in transcriptional regulation. | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | 0.452 |
ZNF471 | FAM228B | ENSP00000309161 | ENSP00000482482 | Zinc finger protein 471; May be involved in transcriptional regulation. | Protein FAM228B; Family with sequence similarity 228 member B; Belongs to the FAM228 family. | 0.478 |
ZNF471 | KIAA1755 | ENSP00000309161 | ENSP00000279024 | Zinc finger protein 471; May be involved in transcriptional regulation. | Uncharacterized protein KIAA1755; KIAA1755. | 0.450 |
ZNF471 | MIS18A | ENSP00000309161 | ENSP00000290130 | Zinc finger protein 471; May be involved in transcriptional regulation. | Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. | 0.457 |
ZNF471 | SLFN12 | ENSP00000309161 | ENSP00000378063 | Zinc finger protein 471; May be involved in transcriptional regulation. | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.458 |
ZNF471 | THOC5 | ENSP00000309161 | ENSP00000420306 | Zinc finger protein 471; May be involved in transcriptional regulation. | THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essentia [...] | 0.433 |