STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBY2Chibby family member 2. (448 aa)    
Predicted Functional Partners:
MLH1
DNA mismatch repair protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...]
    
   0.712
CBY3
Chibby family member 3.
      
 0.708
FAM187B
Protein FAM187B; Family with sequence similarity 187 member B.
   
  
 0.650
SPATA3
Spermatogenesis-associated protein 3; Spermatogenesis associated 3.
   
 
 0.610
KCTD4
BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4.
   
  
 0.605
OR7G3
Olfactory receptor 7G3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.601
SPEM1
Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis.
   
  
 0.588
GTF2F2
General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.
    
 
 0.572
TMEM210
Transmembrane protein 210.
      
 0.558
SPATC1
Speriolin; Spermatogenesis and centriole associated 1; Belongs to the speriolin family.
   
  
 0.555
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.