node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf88 | NWD2 | ENSP00000333845 | ENSP00000309501 | UPF0722 protein C11orf88. | NACHT and WD repeat domain containing 2. | 0.484 |
DMTN | FAM171B | ENSP00000427866 | ENSP00000304108 | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family. | 0.408 |
DMTN | NWD2 | ENSP00000427866 | ENSP00000309501 | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | NACHT and WD repeat domain containing 2. | 0.444 |
FAM171B | DMTN | ENSP00000304108 | ENSP00000427866 | Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family. | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | 0.408 |
FAM171B | NWD2 | ENSP00000304108 | ENSP00000309501 | Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family. | NACHT and WD repeat domain containing 2. | 0.515 |
MCC | NWD2 | ENSP00000386227 | ENSP00000309501 | Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2- dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and [...] | NACHT and WD repeat domain containing 2. | 0.493 |
MCC | PXYLP1 | ENSP00000386227 | ENSP00000286353 | Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2- dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and [...] | 2-phosphoxylose phosphatase 1; Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation duri [...] | 0.411 |
MCC | SCML4 | ENSP00000386227 | ENSP00000358016 | Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2- dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and [...] | Sex comb on midleg-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). | 0.438 |
NWD2 | C11orf88 | ENSP00000309501 | ENSP00000333845 | NACHT and WD repeat domain containing 2. | UPF0722 protein C11orf88. | 0.484 |
NWD2 | DMTN | ENSP00000309501 | ENSP00000427866 | NACHT and WD repeat domain containing 2. | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | 0.444 |
NWD2 | FAM171B | ENSP00000309501 | ENSP00000304108 | NACHT and WD repeat domain containing 2. | Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family. | 0.515 |
NWD2 | MCC | ENSP00000309501 | ENSP00000386227 | NACHT and WD repeat domain containing 2. | Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2- dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and [...] | 0.493 |
NWD2 | PLAGL2 | ENSP00000309501 | ENSP00000246229 | NACHT and WD repeat domain containing 2. | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.481 |
NWD2 | PXYLP1 | ENSP00000309501 | ENSP00000286353 | NACHT and WD repeat domain containing 2. | 2-phosphoxylose phosphatase 1; Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation duri [...] | 0.512 |
NWD2 | RIPK4 | ENSP00000309501 | ENSP00000332454 | NACHT and WD repeat domain containing 2. | Receptor-interacting serine/threonine-protein kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. | 0.451 |
NWD2 | SACS | ENSP00000309501 | ENSP00000371729 | NACHT and WD repeat domain containing 2. | Sacsin; Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. | 0.539 |
NWD2 | SCML4 | ENSP00000309501 | ENSP00000358016 | NACHT and WD repeat domain containing 2. | Sex comb on midleg-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). | 0.447 |
NWD2 | WDR93 | ENSP00000309501 | ENSP00000268130 | NACHT and WD repeat domain containing 2. | WD repeat domain 93. | 0.527 |
PLAGL2 | NWD2 | ENSP00000246229 | ENSP00000309501 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family. | NACHT and WD repeat domain containing 2. | 0.481 |
PXYLP1 | MCC | ENSP00000286353 | ENSP00000386227 | 2-phosphoxylose phosphatase 1; Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation duri [...] | Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2- dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and [...] | 0.411 |