STRINGSTRING
SPNS1 protein (human) - STRING interaction network
"SPNS1" - Protein spinster homolog 1 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SPNS1Protein spinster homolog 1; Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death (528 aa)    
Predicted Functional Partners:
BCL2L1
Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family (233 aa)
       
 
  0.910
UNC93A
Unc-93 homolog A; Belongs to the unc-93 family (457 aa)
           
  0.672
CTSD
Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins (412 aa)
     
   
  0.634
PDF
Peptide deformylase, mitochondrial; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family (243 aa)
     
   
  0.632
TUFM
Elongation factor Tu, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily (455 aa)
     
   
  0.609
MFSD9
Major facilitator superfamily domain containing 9 (474 aa)
     
   
  0.606
SVOP
Synaptic vesicle 2-related protein; SV2 related protein (548 aa)
     
 
  0.600
C6orf222
Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 (652 aa)
           
  0.587
RABEP2
Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion; Belongs to the rabaptin family (569 aa)
           
  0.583
SH2B1
SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated (’Tyr-813’) JAK2 recruits SH2B1, which in turn is phosphoryla [...] (756 aa)
     
   
  0.579
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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