node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTD | HLCS | ENSP00000500193 | ENSP00000382071 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. | 0.996 |
BTD | SLC19A2 | ENSP00000500193 | ENSP00000236137 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.619 |
BTD | SLC5A6 | ENSP00000500193 | ENSP00000310208 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.555 |
DPH2 | SLC5A6 | ENSP00000255108 | ENSP00000310208 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.471 |
HLCS | BTD | ENSP00000382071 | ENSP00000500193 | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.996 |
HLCS | SLC5A6 | ENSP00000382071 | ENSP00000310208 | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.635 |
PDZD11 | SLC5A6 | ENSP00000239666 | ENSP00000310208 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.969 |
SLC19A2 | BTD | ENSP00000236137 | ENSP00000500193 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.619 |
SLC19A2 | SLC5A6 | ENSP00000236137 | ENSP00000310208 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.469 |
SLC22A12 | SLC26A4 | ENSP00000366797 | ENSP00000494017 | Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.519 |
SLC22A12 | SLC5A6 | ENSP00000366797 | ENSP00000310208 | Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.631 |
SLC23A1 | SLC5A6 | ENSP00000302851 | ENSP00000310208 | Solute carrier family 23 member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.493 |
SLC26A4 | SLC22A12 | ENSP00000494017 | ENSP00000366797 | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.519 |
SLC26A4 | SLC5A6 | ENSP00000494017 | ENSP00000310208 | Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.578 |
SLC5A3 | SLC5A6 | ENSP00000370543 | ENSP00000310208 | Sodium/myo-inositol cotransporter; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.511 |
SLC5A6 | BTD | ENSP00000310208 | ENSP00000500193 | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.555 |
SLC5A6 | DPH2 | ENSP00000310208 | ENSP00000255108 | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | 0.471 |
SLC5A6 | HLCS | ENSP00000310208 | ENSP00000382071 | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. | 0.635 |
SLC5A6 | PDZD11 | ENSP00000310208 | ENSP00000239666 | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.969 |
SLC5A6 | SLC19A2 | ENSP00000310208 | ENSP00000236137 | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.469 |