STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RTP1Receptor-transporting protein 1; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs; Belongs to the TMEM7 family. (263 aa)    
Predicted Functional Partners:
REEP1
Receptor expression-enhancing protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors. May play a role in long-term axonal maintenance.
   
 
 0.974
OR2B3
Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.697
OR7D4
Olfactory receptor 7D4; Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.
    
 0.689
OR2M7
Olfactory receptor 2M7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.675
CNGA2
Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
      
 0.673
RIC8B
Synembryn-B; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction; Belongs to the synembryn family.
      
 0.664
OR2A7
Olfactory receptor 2A7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.614
OR2L13
Olfactory receptor 2L13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
 0.613
OR11H4
Olfactory receptor 11H4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.612
OR5D18
Olfactory receptor 5D18; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.596
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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