node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C17orf64 | DHX40 | ENSP00000269127 | ENSP00000251241 | Uncharacterized protein C17orf64; Chromosome 17 open reading frame 64. | Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.499 |
C17orf64 | YPEL2 | ENSP00000269127 | ENSP00000312272 | Uncharacterized protein C17orf64; Chromosome 17 open reading frame 64. | Protein yippee-like 2; Yippee like 2. | 0.427 |
CREBRF | KLHL24 | ENSP00000296953 | ENSP00000395012 | CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. | Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). | 0.759 |
CREBRF | YPEL2 | ENSP00000296953 | ENSP00000312272 | CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. | Protein yippee-like 2; Yippee like 2. | 0.467 |
DHX40 | C17orf64 | ENSP00000251241 | ENSP00000269127 | Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Uncharacterized protein C17orf64; Chromosome 17 open reading frame 64. | 0.499 |
DHX40 | YPEL2 | ENSP00000251241 | ENSP00000312272 | Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | Protein yippee-like 2; Yippee like 2. | 0.634 |
FBXL20 | YPEL2 | ENSP00000264658 | ENSP00000312272 | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). | Protein yippee-like 2; Yippee like 2. | 0.414 |
KLHL24 | CREBRF | ENSP00000395012 | ENSP00000296953 | Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). | CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. | 0.759 |
KLHL24 | YPEL2 | ENSP00000395012 | ENSP00000312272 | Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). | Protein yippee-like 2; Yippee like 2. | 0.428 |
WDR26 | YPEL2 | ENSP00000498603 | ENSP00000312272 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubi [...] | Protein yippee-like 2; Yippee like 2. | 0.481 |
YPEL2 | C17orf64 | ENSP00000312272 | ENSP00000269127 | Protein yippee-like 2; Yippee like 2. | Uncharacterized protein C17orf64; Chromosome 17 open reading frame 64. | 0.427 |
YPEL2 | CREBRF | ENSP00000312272 | ENSP00000296953 | Protein yippee-like 2; Yippee like 2. | CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. | 0.467 |
YPEL2 | DHX40 | ENSP00000312272 | ENSP00000251241 | Protein yippee-like 2; Yippee like 2. | Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.634 |
YPEL2 | FBXL20 | ENSP00000312272 | ENSP00000264658 | Protein yippee-like 2; Yippee like 2. | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). | 0.414 |
YPEL2 | KLHL24 | ENSP00000312272 | ENSP00000395012 | Protein yippee-like 2; Yippee like 2. | Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). | 0.428 |
YPEL2 | WDR26 | ENSP00000312272 | ENSP00000498603 | Protein yippee-like 2; Yippee like 2. | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubi [...] | 0.481 |