node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPHD1 | C16orf54 | ENSP00000311447 | ENSP00000327506 | Aspartate beta-hydroxylase domain containing 1. | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | 0.803 |
ASPHD1 | DOC2A | ENSP00000311447 | ENSP00000482870 | Aspartate beta-hydroxylase domain containing 1. | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | 0.684 |
ASPHD1 | HIRIP3 | ENSP00000311447 | ENSP00000279392 | Aspartate beta-hydroxylase domain containing 1. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.693 |
ASPHD1 | INO80E | ENSP00000311447 | ENSP00000457016 | Aspartate beta-hydroxylase domain containing 1. | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.678 |
ASPHD1 | KCTD13 | ENSP00000311447 | ENSP00000455785 | Aspartate beta-hydroxylase domain containing 1. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). Belongs to the BACURD family. | 0.814 |
ASPHD1 | KIF22 | ENSP00000311447 | ENSP00000160827 | Aspartate beta-hydroxylase domain containing 1. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | 0.661 |
ASPHD1 | PRRT2 | ENSP00000311447 | ENSP00000456226 | Aspartate beta-hydroxylase domain containing 1. | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | 0.619 |
ASPHD1 | SEZ6L2 | ENSP00000311447 | ENSP00000481917 | Aspartate beta-hydroxylase domain containing 1. | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | 0.869 |
ASPHD1 | TAOK2 | ENSP00000311447 | ENSP00000310094 | Aspartate beta-hydroxylase domain containing 1. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.600 |
ASPHD1 | YPEL3 | ENSP00000311447 | ENSP00000381821 | Aspartate beta-hydroxylase domain containing 1. | Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. | 0.687 |
C16orf54 | ASPHD1 | ENSP00000327506 | ENSP00000311447 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Aspartate beta-hydroxylase domain containing 1. | 0.803 |
C16orf54 | DOC2A | ENSP00000327506 | ENSP00000482870 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | 0.600 |
C16orf54 | HIRIP3 | ENSP00000327506 | ENSP00000279392 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.664 |
C16orf54 | INO80E | ENSP00000327506 | ENSP00000457016 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.596 |
C16orf54 | KCTD13 | ENSP00000327506 | ENSP00000455785 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). Belongs to the BACURD family. | 0.601 |
C16orf54 | KIF22 | ENSP00000327506 | ENSP00000160827 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | 0.542 |
C16orf54 | PRRT2 | ENSP00000327506 | ENSP00000456226 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | 0.507 |
C16orf54 | SEZ6L2 | ENSP00000327506 | ENSP00000481917 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | 0.609 |
C16orf54 | TAOK2 | ENSP00000327506 | ENSP00000310094 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.585 |
C16orf54 | YPEL3 | ENSP00000327506 | ENSP00000381821 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. | 0.600 |