node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHBP1 | EHBP1L1 | ENSP00000263991 | ENSP00000312671 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | 0.620 |
EHBP1 | PDLIM1 | ENSP00000263991 | ENSP00000360305 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | PDZ and LIM domain protein 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). | 0.612 |
EHBP1 | PDLIM2 | ENSP00000263991 | ENSP00000312634 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. | 0.612 |
EHBP1 | PDLIM3 | ENSP00000263991 | ENSP00000284767 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells. | 0.612 |
EHBP1 | PDLIM4 | ENSP00000263991 | ENSP00000253754 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | PDZ and LIM domain protein 4; [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport [...] | 0.612 |
EHBP1 | PDLIM5 | ENSP00000263991 | ENSP00000480359 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | PDZ and LIM domain 5. | 0.717 |
EHBP1 | PDLIM7 | ENSP00000263991 | ENSP00000348099 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). | 0.612 |
EHBP1 | RAB8A | ENSP00000263991 | ENSP00000300935 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.986 |
EHBP1 | RILPL1 | ENSP00000263991 | ENSP00000366070 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis. ECO:0000250|UniPro [...] | 0.504 |
EHBP1L1 | EHBP1 | ENSP00000312671 | ENSP00000263991 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | 0.620 |
EHBP1L1 | PDLIM1 | ENSP00000312671 | ENSP00000360305 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | PDZ and LIM domain protein 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). | 0.616 |
EHBP1L1 | PDLIM2 | ENSP00000312671 | ENSP00000312634 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. | 0.619 |
EHBP1L1 | PDLIM3 | ENSP00000312671 | ENSP00000284767 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells. | 0.615 |
EHBP1L1 | PDLIM4 | ENSP00000312671 | ENSP00000253754 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | PDZ and LIM domain protein 4; [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport [...] | 0.618 |
EHBP1L1 | PDLIM5 | ENSP00000312671 | ENSP00000480359 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | PDZ and LIM domain 5. | 0.615 |
EHBP1L1 | PDLIM7 | ENSP00000312671 | ENSP00000348099 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). | 0.656 |
EHBP1L1 | RAB8A | ENSP00000312671 | ENSP00000300935 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.850 |
EHBP1L1 | RILPL1 | ENSP00000312671 | ENSP00000366070 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis. ECO:0000250|UniPro [...] | 0.644 |
EHBP1L1 | TIGD3 | ENSP00000312671 | ENSP00000308354 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking. | Tigger transposable element derived 3. | 0.609 |
PDLIM1 | EHBP1 | ENSP00000360305 | ENSP00000263991 | PDZ and LIM domain protein 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin- regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). | 0.612 |