node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C5orf58 | GTSF1L | ENSP00000490013 | ENSP00000362094 | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58. | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like. | 0.503 |
C5orf58 | HSF5 | ENSP00000490013 | ENSP00000313243 | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58. | Heat shock factor protein 5; May act as a transcriptional factor. | 0.418 |
DNAJB1 | HSF5 | ENSP00000254322 | ENSP00000313243 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock factor protein 5; May act as a transcriptional factor. | 0.471 |
DNAJB1 | HSPA4 | ENSP00000254322 | ENSP00000302961 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.999 |
DNAJB1 | HSPB7 | ENSP00000254322 | ENSP00000364870 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock protein family B member 7; Belongs to the small heat shock protein (HSP20) family. | 0.473 |
DNAJB1 | HYOU1 | ENSP00000254322 | ENSP00000480150 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Belongs to the heat shock protein 70 family. | 0.765 |
GTSF1L | C5orf58 | ENSP00000362094 | ENSP00000490013 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like. | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58. | 0.503 |
GTSF1L | HSF5 | ENSP00000362094 | ENSP00000313243 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like. | Heat shock factor protein 5; May act as a transcriptional factor. | 0.476 |
HRC | HSF5 | ENSP00000252825 | ENSP00000313243 | Sarcoplasmic reticulum histidine-rich calcium-binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. | Heat shock factor protein 5; May act as a transcriptional factor. | 0.573 |
HSF5 | C5orf58 | ENSP00000313243 | ENSP00000490013 | Heat shock factor protein 5; May act as a transcriptional factor. | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58. | 0.418 |
HSF5 | DNAJB1 | ENSP00000313243 | ENSP00000254322 | Heat shock factor protein 5; May act as a transcriptional factor. | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.471 |
HSF5 | GTSF1L | ENSP00000313243 | ENSP00000362094 | Heat shock factor protein 5; May act as a transcriptional factor. | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like. | 0.476 |
HSF5 | HRC | ENSP00000313243 | ENSP00000252825 | Heat shock factor protein 5; May act as a transcriptional factor. | Sarcoplasmic reticulum histidine-rich calcium-binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. | 0.573 |
HSF5 | HSPA4 | ENSP00000313243 | ENSP00000302961 | Heat shock factor protein 5; May act as a transcriptional factor. | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.405 |
HSF5 | HSPB7 | ENSP00000313243 | ENSP00000364870 | Heat shock factor protein 5; May act as a transcriptional factor. | Heat shock protein family B member 7; Belongs to the small heat shock protein (HSP20) family. | 0.426 |
HSF5 | HYOU1 | ENSP00000313243 | ENSP00000480150 | Heat shock factor protein 5; May act as a transcriptional factor. | Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Belongs to the heat shock protein 70 family. | 0.445 |
HSF5 | YBX2 | ENSP00000313243 | ENSP00000007699 | Heat shock factor protein 5; May act as a transcriptional factor. | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA- 3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplas [...] | 0.430 |
HSPA4 | DNAJB1 | ENSP00000302961 | ENSP00000254322 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.999 |
HSPA4 | HSF5 | ENSP00000302961 | ENSP00000313243 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Heat shock factor protein 5; May act as a transcriptional factor. | 0.405 |
HSPA4 | HSPB7 | ENSP00000302961 | ENSP00000364870 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Heat shock protein family B member 7; Belongs to the small heat shock protein (HSP20) family. | 0.516 |