node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2 | CALML5 | ENSP00000381185 | ENSP00000369689 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | 0.505 |
BCL2 | LGALS7 | ENSP00000381185 | ENSP00000367891 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. | Galectin 7. | 0.822 |
BCL2 | LGALS7B | ENSP00000381185 | ENSP00000313571 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. | Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. | 0.822 |
BCL2 | SMAD3 | ENSP00000381185 | ENSP00000332973 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.578 |
CALML5 | BCL2 | ENSP00000369689 | ENSP00000381185 | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. | 0.505 |
CALML5 | CHD7 | ENSP00000369689 | ENSP00000392028 | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | 0.654 |
CALML5 | KRT2 | ENSP00000369689 | ENSP00000310861 | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | 0.476 |
CALML5 | KRTDAP | ENSP00000369689 | ENSP00000339251 | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.444 |
CALML5 | LGALS7 | ENSP00000369689 | ENSP00000367891 | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | Galectin 7. | 0.548 |
CALML5 | LGALS7B | ENSP00000369689 | ENSP00000313571 | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. | 0.562 |
CHD7 | CALML5 | ENSP00000392028 | ENSP00000369689 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | 0.654 |
CHD7 | LGALS7 | ENSP00000392028 | ENSP00000367891 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | Galectin 7. | 0.602 |
CHD7 | LGALS7B | ENSP00000392028 | ENSP00000313571 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. | 0.602 |
CHD7 | PAICS | ENSP00000392028 | ENSP00000382595 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. | 0.946 |
KRT2 | CALML5 | ENSP00000310861 | ENSP00000369689 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | 0.476 |
KRT2 | KRTDAP | ENSP00000310861 | ENSP00000339251 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | 0.614 |
KRT2 | LGALS7 | ENSP00000310861 | ENSP00000367891 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Galectin 7. | 0.582 |
KRT2 | LGALS7B | ENSP00000310861 | ENSP00000313571 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. | 0.567 |
KRTDAP | CALML5 | ENSP00000339251 | ENSP00000369689 | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes. | 0.444 |
KRTDAP | KRT2 | ENSP00000339251 | ENSP00000310861 | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | 0.614 |