node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMPD3 | NIM1K | ENSP00000379802 | ENSP00000420849 | AMP deaminase 3; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.419 |
CCDC152 | NIM1K | ENSP00000354888 | ENSP00000420849 | Coiled-coil domain containing 152. | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.429 |
CCDC152 | ZNF131 | ENSP00000354888 | ENSP00000426504 | Coiled-coil domain containing 152. | Zinc finger protein 131; Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. | 0.456 |
GPR26 | NIM1K | ENSP00000284674 | ENSP00000420849 | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.416 |
GPR26 | PCP4L1 | ENSP00000284674 | ENSP00000426296 | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. | Purkinje cell protein 4 like 1; Belongs to the PCP4 family. | 0.486 |
MYBPC2 | NIM1K | ENSP00000350332 | ENSP00000420849 | Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.421 |
NIM1K | AMPD3 | ENSP00000420849 | ENSP00000379802 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | AMP deaminase 3; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.419 |
NIM1K | CCDC152 | ENSP00000420849 | ENSP00000354888 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Coiled-coil domain containing 152. | 0.429 |
NIM1K | GPR26 | ENSP00000420849 | ENSP00000284674 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. | 0.416 |
NIM1K | MYBPC2 | ENSP00000420849 | ENSP00000350332 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family. | 0.421 |
NIM1K | PCP4L1 | ENSP00000420849 | ENSP00000426296 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Purkinje cell protein 4 like 1; Belongs to the PCP4 family. | 0.487 |
NIM1K | PLA2G4D | ENSP00000420849 | ENSP00000290472 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | 0.434 |
NIM1K | TNK2 | ENSP00000420849 | ENSP00000371341 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Activated CDC42 kinase 1; Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting [...] | 0.408 |
NIM1K | TPCN1 | ENSP00000420849 | ENSP00000448083 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Two pore calcium channel protein 1; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. | 0.453 |
NIM1K | WEE1 | ENSP00000420849 | ENSP00000402084 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Wee1-like protein kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase wh [...] | 0.447 |
NIM1K | ZNF131 | ENSP00000420849 | ENSP00000426504 | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Zinc finger protein 131; Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. | 0.452 |
PCP4L1 | GPR26 | ENSP00000426296 | ENSP00000284674 | Purkinje cell protein 4 like 1; Belongs to the PCP4 family. | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. | 0.486 |
PCP4L1 | NIM1K | ENSP00000426296 | ENSP00000420849 | Purkinje cell protein 4 like 1; Belongs to the PCP4 family. | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.487 |
PLA2G4D | NIM1K | ENSP00000290472 | ENSP00000420849 | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.434 |
TNK2 | NIM1K | ENSP00000371341 | ENSP00000420849 | Activated CDC42 kinase 1; Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting [...] | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.408 |