node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRV1 | LYSMD3 | ENSP00000384582 | ENSP00000314518 | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.499 |
ARL6IP1 | LYSMD3 | ENSP00000306788 | ENSP00000314518 | ADP-ribosylation factor-like protein 6-interacting protein 1; Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity- dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-depend [...] | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.424 |
ARRDC3 | LYSMD3 | ENSP00000265138 | ENSP00000314518 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.549 |
CETN3 | LYSMD3 | ENSP00000428259 | ENSP00000314518 | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function. | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.428 |
CETN3 | MBLAC2 | ENSP00000428259 | ENSP00000314776 | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function. | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.437 |
DNAJC25-GNG10 | LYSMD3 | ENSP00000363412 | ENSP00000314518 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.480 |
FAM174B | LYSMD3 | ENSP00000329040 | ENSP00000314518 | Membrane protein FAM174B; Essential for Golgi structural integrity. | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.496 |
LYSMD2 | LYSMD3 | ENSP00000267838 | ENSP00000314518 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2. | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.432 |
LYSMD3 | ADGRV1 | ENSP00000314518 | ENSP00000384582 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | 0.499 |
LYSMD3 | ARL6IP1 | ENSP00000314518 | ENSP00000306788 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | ADP-ribosylation factor-like protein 6-interacting protein 1; Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity- dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-depend [...] | 0.424 |
LYSMD3 | ARRDC3 | ENSP00000314518 | ENSP00000265138 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | 0.549 |
LYSMD3 | CETN3 | ENSP00000314518 | ENSP00000428259 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function. | 0.428 |
LYSMD3 | DNAJC25-GNG10 | ENSP00000314518 | ENSP00000363412 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.480 |
LYSMD3 | FAM174B | ENSP00000314518 | ENSP00000329040 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Membrane protein FAM174B; Essential for Golgi structural integrity. | 0.496 |
LYSMD3 | LYSMD2 | ENSP00000314518 | ENSP00000267838 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2. | 0.432 |
LYSMD3 | MBLAC2 | ENSP00000314518 | ENSP00000314776 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.650 |
LYSMD3 | PCDH18 | ENSP00000314518 | ENSP00000355082 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | 0.457 |
LYSMD3 | POLR3G | ENSP00000314518 | ENSP00000498469 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | DNA-directed RNA polymerase III subunit RPC7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating cata [...] | 0.461 |
MBLAC2 | CETN3 | ENSP00000314776 | ENSP00000428259 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function. | 0.437 |
MBLAC2 | LYSMD3 | ENSP00000314776 | ENSP00000314518 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.650 |