STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDDM3BEpididymal secretory protein E3-beta; Possible function in sperm maturation. (147 aa)    
Predicted Functional Partners:
LRCOL1
Leucine-rich colipase-like protein 1; Leucine rich colipase like 1.
      
 0.567
WFDC8
WAP four-disulfide core domain 8.
   
  
 0.537
WFDC9
Protein WFDC9; WAP four-disulfide core domain 9.
   
  
 0.498
TEX101
Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).
   
 
 0.489
C7orf31
Uncharacterized protein C7orf31; Chromosome 7 open reading frame 31.
      
 0.475
FAM229B
Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family.
      
 0.475
GOLGA8F
Golgin A8 family member F; Belongs to the GOLGA8 family.
      
 0.473
CRISP1
Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family.
   
  
 0.463
PTGER3
Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to muco [...]
   
  
 0.451
WFDC11
Protein WFDC11; WAP four-disulfide core domain 11.
   
  
 0.444
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.