CREG2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CREG2

Protein CREG2; Cellular repressor of E1A stimulated genes 2. (290 aa)

Predicted Functional Partners:

SREK1IP1

0.518

ZNF572

0.498

STPG4

0.476

PCP2

0.461

ZNF28

0.460

SFXN3

0.454

ZNF85

0.452

ZNF708

0.451

SH3TC2

0.428

LEMD3

0.425

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREG2	LEMD3	ENSP00000315203	ENSP00000308369	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	0.425
CREG2	PCP2	ENSP00000315203	ENSP00000310585	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Purkinje cell protein 2 homolog; May function as a cell-type specific modulator for G protein- mediated cell signaling.	0.461
CREG2	SFXN3	ENSP00000315203	ENSP00000224807	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family.	0.454
CREG2	SH3TC2	ENSP00000315203	ENSP00000423660	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	SH3 domain and tetratricopeptide repeats 2.	0.428
CREG2	SREK1IP1	ENSP00000315203	ENSP00000427401	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival.	0.518
CREG2	STPG4	ENSP00000315203	ENSP00000408527	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC).	0.476
CREG2	ZNF28	ENSP00000315203	ENSP00000397693	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Zinc finger protein 28; May be involved in transcriptional regulation.	0.460
CREG2	ZNF572	ENSP00000315203	ENSP00000319305	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Zinc finger protein 572; May be involved in transcriptional regulation.	0.498
CREG2	ZNF708	ENSP00000315203	ENSP00000349401	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Zinc finger protein 708; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.451
CREG2	ZNF85	ENSP00000315203	ENSP00000329793	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	Zinc finger protein 85; May be a transcriptional repressor.	0.452
LEMD3	CREG2	ENSP00000308369	ENSP00000315203	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	0.425
LEMD3	SFXN3	ENSP00000308369	ENSP00000224807	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family.	0.403
LEMD3	SREK1IP1	ENSP00000308369	ENSP00000427401	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival.	0.423
LEMD3	ZNF28	ENSP00000308369	ENSP00000397693	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	Zinc finger protein 28; May be involved in transcriptional regulation.	0.445
LEMD3	ZNF572	ENSP00000308369	ENSP00000319305	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	Zinc finger protein 572; May be involved in transcriptional regulation.	0.436
LEMD3	ZNF708	ENSP00000308369	ENSP00000349401	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	Zinc finger protein 708; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.451
LEMD3	ZNF85	ENSP00000308369	ENSP00000329793	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	Zinc finger protein 85; May be a transcriptional repressor.	0.407
PCP2	CREG2	ENSP00000310585	ENSP00000315203	Purkinje cell protein 2 homolog; May function as a cell-type specific modulator for G protein- mediated cell signaling.	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	0.461
SFXN3	CREG2	ENSP00000224807	ENSP00000315203	Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family.	Protein CREG2; Cellular repressor of E1A stimulated genes 2.	0.454
SFXN3	LEMD3	ENSP00000224807	ENSP00000308369	Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family.	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	0.403