node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf91 | DEPDC7 | ENSP00000368296 | ENSP00000241051 | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. | DEP domain containing 7; Belongs to the DEPDC7 family. | 0.418 |
C11orf91 | FBXO3 | ENSP00000368296 | ENSP00000265651 | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. | 0.604 |
C11orf91 | KIAA1549L | ENSP00000368296 | ENSP00000315295 | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.446 |
CD59 | CSTF3 | ENSP00000498879 | ENSP00000315791 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | 0.548 |
CD59 | KIAA1549L | ENSP00000498879 | ENSP00000315295 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.668 |
CSTF1 | CSTF3 | ENSP00000217109 | ENSP00000315791 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | 0.999 |
CSTF1 | DEPDC7 | ENSP00000217109 | ENSP00000241051 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | DEP domain containing 7; Belongs to the DEPDC7 family. | 0.531 |
CSTF1 | KIAA1549L | ENSP00000217109 | ENSP00000315295 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.495 |
CSTF3 | CD59 | ENSP00000315791 | ENSP00000498879 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | 0.548 |
CSTF3 | CSTF1 | ENSP00000315791 | ENSP00000217109 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | 0.999 |
CSTF3 | DEPDC7 | ENSP00000315791 | ENSP00000241051 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | DEP domain containing 7; Belongs to the DEPDC7 family. | 0.929 |
CSTF3 | KIAA1549L | ENSP00000315791 | ENSP00000315295 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.909 |
DEPDC7 | C11orf91 | ENSP00000241051 | ENSP00000368296 | DEP domain containing 7; Belongs to the DEPDC7 family. | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. | 0.418 |
DEPDC7 | CSTF1 | ENSP00000241051 | ENSP00000217109 | DEP domain containing 7; Belongs to the DEPDC7 family. | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | 0.531 |
DEPDC7 | CSTF3 | ENSP00000241051 | ENSP00000315791 | DEP domain containing 7; Belongs to the DEPDC7 family. | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | 0.929 |
DEPDC7 | KIAA1549L | ENSP00000241051 | ENSP00000315295 | DEP domain containing 7; Belongs to the DEPDC7 family. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.874 |
DNAH14 | KIAA1549L | ENSP00000383737 | ENSP00000315295 | Dynein axonemal heavy chain 14. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.439 |
DPRX | KIAA1549L | ENSP00000365838 | ENSP00000315295 | Divergent paired-related homeobox; Putative transcription factor; Belongs to the paired homeobox family. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.476 |
FBXO3 | C11orf91 | ENSP00000265651 | ENSP00000368296 | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. | 0.604 |
FBXO3 | KIAA1549L | ENSP00000265651 | ENSP00000315295 | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family. | 0.872 |