| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOC3 | ARL6IP6 | ENSP00000312326 | ENSP00000315357 | Membrane primary amine oxidase; Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.583 |
| APPL1 | ARL6IP6 | ENSP00000288266 | ENSP00000315357 | DCC-interacting protein 13-alpha; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated pha [...] | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.763 |
| APPL1 | TRAPPC11 | ENSP00000288266 | ENSP00000335371 | DCC-interacting protein 13-alpha; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated pha [...] | Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. | 0.723 |
| ARL6IP6 | AOC3 | ENSP00000315357 | ENSP00000312326 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | Membrane primary amine oxidase; Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. | 0.583 |
| ARL6IP6 | APPL1 | ENSP00000315357 | ENSP00000288266 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | DCC-interacting protein 13-alpha; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated pha [...] | 0.763 |
| ARL6IP6 | CRTC2 | ENSP00000315357 | ENSP00000357622 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | CREB-regulated transcription coactivator 2; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mit [...] | 0.816 |
| ARL6IP6 | DUSP3 | ENSP00000315357 | ENSP00000226004 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. | 0.742 |
| ARL6IP6 | FMNL2 | ENSP00000315357 | ENSP00000288670 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | Formin-like protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics; Belongs to the formin homology family. | 0.558 |
| ARL6IP6 | KLC2 | ENSP00000315357 | ENSP00000399403 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | Kinesin light chain 2; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). | 0.675 |
| ARL6IP6 | NAA50 | ENSP00000315357 | ENSP00000240922 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...] | 0.626 |
| ARL6IP6 | PNPO | ENSP00000315357 | ENSP00000493302 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | Pyridoxine-5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.617 |
| ARL6IP6 | TRAPPC11 | ENSP00000315357 | ENSP00000335371 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. | 0.693 |
| ARL6IP6 | TRAPPC4 | ENSP00000315357 | ENSP00000436005 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi. | 0.562 |
| CRTC2 | ARL6IP6 | ENSP00000357622 | ENSP00000315357 | CREB-regulated transcription coactivator 2; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mit [...] | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.816 |
| DUSP3 | ARL6IP6 | ENSP00000226004 | ENSP00000315357 | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.742 |
| FMNL2 | ARL6IP6 | ENSP00000288670 | ENSP00000315357 | Formin-like protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics; Belongs to the formin homology family. | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.558 |
| KLC2 | ARL6IP6 | ENSP00000399403 | ENSP00000315357 | Kinesin light chain 2; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.675 |
| KLC2 | TRAPPC11 | ENSP00000399403 | ENSP00000335371 | Kinesin light chain 2; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). | Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. | 0.599 |
| NAA50 | ARL6IP6 | ENSP00000240922 | ENSP00000315357 | N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...] | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.626 |
| PNPO | ARL6IP6 | ENSP00000493302 | ENSP00000315357 | Pyridoxine-5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family. | 0.617 |
