STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C5orf46Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46. (87 aa)    
Predicted Functional Partners:
WFDC5
WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor.
   
  
 0.581
TMBIM6
Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
    
 
 0.470
GPR87
G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family.
   
  
 0.468
ADGRF4
Adhesion G protein-coupled receptor F4; Orphan receptor.
   
  
 0.457
MUCL1
Mucin-like protein 1; May play a role as marker for the diagnosis of metastatic breast cancer.
   
  
 0.453
SERPINB7
Serpin B7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.
   
  
 0.444
IGFL2
Insulin growth factor-like family member 2; Potential ligand of the IGFLR1 cell membrane receptor.
   
  
 0.428
SUMO4
Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by t [...]
      
 0.419
CDHR1
Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).
      
 0.418
TMEM45A
Transmembrane protein 45A.
   
  
 0.415
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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