node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBY2 | SPATA16 | ENSP00000309189 | ENSP00000341765 | Chibby family member 2. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.474 |
CBY2 | SPATA3 | ENSP00000309189 | ENSP00000388895 | Chibby family member 2. | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. | 0.610 |
CBY2 | SPEM1 | ENSP00000309189 | ENSP00000315554 | Chibby family member 2. | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. | 0.588 |
CBY2 | TSSK6 | ENSP00000309189 | ENSP00000466477 | Chibby family member 2. | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | 0.471 |
JUP | SPEM1 | ENSP00000377508 | ENSP00000315554 | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. | 0.585 |
PPP1R1A | SPEM1 | ENSP00000257905 | ENSP00000315554 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. | 0.569 |
PRM2 | SPATA16 | ENSP00000403681 | ENSP00000341765 | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.403 |
PRM2 | SPATA3 | ENSP00000403681 | ENSP00000388895 | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. | 0.545 |
PRM2 | SPEM1 | ENSP00000403681 | ENSP00000315554 | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. | 0.674 |
PRM2 | TNP1 | ENSP00000403681 | ENSP00000236979 | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 1 family. | 0.966 |
PRM2 | TNP2 | ENSP00000403681 | ENSP00000325738 | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. | 0.983 |
PRM2 | TSSK6 | ENSP00000403681 | ENSP00000466477 | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | 0.571 |
SPATA16 | CBY2 | ENSP00000341765 | ENSP00000309189 | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | Chibby family member 2. | 0.474 |
SPATA16 | PRM2 | ENSP00000341765 | ENSP00000403681 | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.403 |
SPATA16 | SPATA3 | ENSP00000341765 | ENSP00000388895 | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. | 0.617 |
SPATA16 | SPEM1 | ENSP00000341765 | ENSP00000315554 | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. | 0.600 |
SPATA3 | CBY2 | ENSP00000388895 | ENSP00000309189 | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. | Chibby family member 2. | 0.610 |
SPATA3 | PRM2 | ENSP00000388895 | ENSP00000403681 | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. | Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. | 0.545 |
SPATA3 | SPATA16 | ENSP00000388895 | ENSP00000341765 | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.617 |
SPATA3 | SPEM1 | ENSP00000388895 | ENSP00000315554 | Spermatogenesis-associated protein 3; Spermatogenesis associated 3. | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis. | 0.602 |