ERICH5 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

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... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC8	ERICH5	ENSP00000419413	ENSP00000315614	Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.	Glutamate-rich protein 5; Glutamate rich 5.	0.477
ARMC8	LRRC45	ENSP00000419413	ENSP00000306760	Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.	Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.	0.452
ARMC8	WDR37	ENSP00000419413	ENSP00000263150	Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.	WD repeat domain 37.	0.608
CFTR	ERICH5	ENSP00000003084	ENSP00000315614	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...]	Glutamate-rich protein 5; Glutamate rich 5.	0.481
DDX39A	ERICH5	ENSP00000242776	ENSP00000315614	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	Glutamate-rich protein 5; Glutamate rich 5.	0.484
ERICH5	ARMC8	ENSP00000315614	ENSP00000419413	Glutamate-rich protein 5; Glutamate rich 5.	Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.	0.477
ERICH5	CFTR	ENSP00000315614	ENSP00000003084	Glutamate-rich protein 5; Glutamate rich 5.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...]	0.481
ERICH5	DDX39A	ENSP00000315614	ENSP00000242776	Glutamate-rich protein 5; Glutamate rich 5.	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	0.484
ERICH5	GRTP1	ENSP00000315614	ENSP00000364579	Glutamate-rich protein 5; Glutamate rich 5.	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	0.439
ERICH5	HOXB5	ENSP00000315614	ENSP00000239151	Glutamate-rich protein 5; Glutamate rich 5.	Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	0.480
ERICH5	LRRC45	ENSP00000315614	ENSP00000306760	Glutamate-rich protein 5; Glutamate rich 5.	Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.	0.535
ERICH5	WDR37	ENSP00000315614	ENSP00000263150	Glutamate-rich protein 5; Glutamate rich 5.	WD repeat domain 37.	0.492
GRTP1	ERICH5	ENSP00000364579	ENSP00000315614	Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).	Glutamate-rich protein 5; Glutamate rich 5.	0.439
HOXB5	ERICH5	ENSP00000239151	ENSP00000315614	Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	Glutamate-rich protein 5; Glutamate rich 5.	0.480
LRRC45	ARMC8	ENSP00000306760	ENSP00000419413	Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.	Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.	0.452
LRRC45	ERICH5	ENSP00000306760	ENSP00000315614	Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.	Glutamate-rich protein 5; Glutamate rich 5.	0.535
LRRC45	WDR37	ENSP00000306760	ENSP00000263150	Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.	WD repeat domain 37.	0.476
WDR37	ARMC8	ENSP00000263150	ENSP00000419413	WD repeat domain 37.	Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.	0.608
WDR37	ERICH5	ENSP00000263150	ENSP00000315614	WD repeat domain 37.	Glutamate-rich protein 5; Glutamate rich 5.	0.492
WDR37	LRRC45	ENSP00000263150	ENSP00000306760	WD repeat domain 37.	Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.	0.476