STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPAG11ASperm-associated antigen 11A; May have antimicrobial activity. May also play a role sperm maturation, storage, and protection. (108 aa)    
Predicted Functional Partners:
DEFB113
Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family.
   
  
 0.550
DEFB126
Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...]
   
  
 0.544
C10orf71
Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway.
   
  
 0.507
DEFB119
Defensin beta 119.
   
  
 0.507
WFDC9
Protein WFDC9; WAP four-disulfide core domain 9.
   
  
 0.466
TRIM64B
Putative tripartite motif-containing protein 64B; Tripartite motif containing 64B; Belongs to the TRIM/RBCC family.
      
 0.449
OR5H14
Olfactory receptor 5H14; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.445
TRIM64
Tripartite motif containing 64; Belongs to the TRIM/RBCC family.
      
 0.430
DEFB118
Beta-defensin 118; Has antibacterial activity.
   
  
 0.426
DEFB103B
Defensin beta 103B.
      
 0.425
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.