STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM270Transmembrane protein 270. (265 aa)    
Predicted Functional Partners:
TMEM225
Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.
   
  
 0.690
METTL27
Methyltransferase-like protein 27; Methyltransferase like 27.
   
  
 0.620
TRIM50
E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction; Belongs to the TRIM/RBCC family.
   
  
 0.587
TBL2
Transducin beta like 2.
   
  
 0.585
FAM71F1
Protein FAM71F1; Family with sequence similarity 71 member F1.
   
  
 0.584
GTSF1L
Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like.
   
  
 0.573
SPATS1
Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1.
   
  
 0.562
SPATA3
Spermatogenesis-associated protein 3; Spermatogenesis associated 3.
   
  
 0.544
FSCN3
Fascin-3; Acts as an actin bundling protein; Belongs to the fascin family.
      
 0.531
DNAJC30
DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity).
   
  
 0.511
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.