TMEM270 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG3	TMEM270	ENSP00000358081	ENSP00000316775	BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti- apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.	Transmembrane protein 270.	0.457
DNAJC30	TBL2	ENSP00000378605	ENSP00000307260	DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity).	Transducin beta like 2.	0.523
DNAJC30	TMEM270	ENSP00000378605	ENSP00000316775	DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity).	Transmembrane protein 270.	0.494
DNAJC30	VPS37D	ENSP00000378605	ENSP00000320416	DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity).	Vacuolar protein sorting-associated protein 37D; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation; Belongs to the VPS37 family.	0.441
FAM71E1	TMEM270	ENSP00000472421	ENSP00000316775	Protein FAM71E1; Family with sequence similarity 71 member E1.	Transmembrane protein 270.	0.454
FAM71F1	SPATS1	ENSP00000326652	ENSP00000501191	Protein FAM71F1; Family with sequence similarity 71 member F1.	Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1.	0.464
FAM71F1	TMEM225	ENSP00000326652	ENSP00000364166	Protein FAM71F1; Family with sequence similarity 71 member F1.	Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.	0.620
FAM71F1	TMEM270	ENSP00000326652	ENSP00000316775	Protein FAM71F1; Family with sequence similarity 71 member F1.	Transmembrane protein 270.	0.502
METTL27	TBL2	ENSP00000297873	ENSP00000307260	Methyltransferase-like protein 27; Methyltransferase like 27.	Transducin beta like 2.	0.470
METTL27	TMEM270	ENSP00000297873	ENSP00000316775	Methyltransferase-like protein 27; Methyltransferase like 27.	Transmembrane protein 270.	0.639
METTL27	VPS37D	ENSP00000297873	ENSP00000320416	Methyltransferase-like protein 27; Methyltransferase like 27.	Vacuolar protein sorting-associated protein 37D; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation; Belongs to the VPS37 family.	0.462
SPATS1	FAM71F1	ENSP00000501191	ENSP00000326652	Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1.	Protein FAM71F1; Family with sequence similarity 71 member F1.	0.464
SPATS1	TMEM225	ENSP00000501191	ENSP00000364166	Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1.	Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.	0.590
SPATS1	TMEM270	ENSP00000501191	ENSP00000316775	Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1.	Transmembrane protein 270.	0.480
TBL2	DNAJC30	ENSP00000307260	ENSP00000378605	Transducin beta like 2.	DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity).	0.523
TBL2	METTL27	ENSP00000307260	ENSP00000297873	Transducin beta like 2.	Methyltransferase-like protein 27; Methyltransferase like 27.	0.470
TBL2	TMEM270	ENSP00000307260	ENSP00000316775	Transducin beta like 2.	Transmembrane protein 270.	0.558
TBL2	TRIM50	ENSP00000307260	ENSP00000327994	Transducin beta like 2.	E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction; Belongs to the TRIM/RBCC family.	0.767
TMEM225	FAM71F1	ENSP00000364166	ENSP00000326652	Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.	Protein FAM71F1; Family with sequence similarity 71 member F1.	0.620
TMEM225	SPATS1	ENSP00000364166	ENSP00000501191	Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.	Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1.	0.590