node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf226 | LIMCH1 | ENSP00000413150 | ENSP00000425631 | Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226. | LIM and calponin homology domains 1. | 0.430 |
HIGD1B | LIMCH1 | ENSP00000253410 | ENSP00000425631 | HIG1 hypoxia inducible domain family member 1B. | LIM and calponin homology domains 1. | 0.441 |
HUWE1 | LIMCH1 | ENSP00000340648 | ENSP00000425631 | E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and pro [...] | LIM and calponin homology domains 1. | 0.518 |
LIMCH1 | C1orf226 | ENSP00000425631 | ENSP00000413150 | LIM and calponin homology domains 1. | Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226. | 0.430 |
LIMCH1 | HIGD1B | ENSP00000425631 | ENSP00000253410 | LIM and calponin homology domains 1. | HIG1 hypoxia inducible domain family member 1B. | 0.441 |
LIMCH1 | HUWE1 | ENSP00000425631 | ENSP00000340648 | LIM and calponin homology domains 1. | E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and pro [...] | 0.518 |
LIMCH1 | OTUD6B | ENSP00000425631 | ENSP00000285420 | LIM and calponin homology domains 1. | Deubiquitinase OTUD6B; [Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1. May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation. May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation. May also play a role in proteasome assembly and function. | 0.491 |
LIMCH1 | POF1B | ENSP00000425631 | ENSP00000362238 | LIM and calponin homology domains 1. | Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. | 0.507 |
LIMCH1 | THYN1 | ENSP00000425631 | ENSP00000341657 | LIM and calponin homology domains 1. | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. | 0.433 |
LIMCH1 | TIGD4 | ENSP00000425631 | ENSP00000355162 | LIM and calponin homology domains 1. | Tigger transposable element derived 4. | 0.490 |
LIMCH1 | TMOD1 | ENSP00000425631 | ENSP00000259365 | LIM and calponin homology domains 1. | Tropomodulin-1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. | 0.420 |
LIMCH1 | TMPO | ENSP00000425631 | ENSP00000266732 | LIM and calponin homology domains 1. | Lamina-associated polypeptide 2, isoform alpha; May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. | 0.443 |
LIMCH1 | ZNF445 | ENSP00000425631 | ENSP00000379387 | LIM and calponin homology domains 1. | Zinc finger protein 445; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprint [...] | 0.440 |
OTUD6B | LIMCH1 | ENSP00000285420 | ENSP00000425631 | Deubiquitinase OTUD6B; [Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1. May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation. May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation. May also play a role in proteasome assembly and function. | LIM and calponin homology domains 1. | 0.491 |
POF1B | LIMCH1 | ENSP00000362238 | ENSP00000425631 | Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. | LIM and calponin homology domains 1. | 0.507 |
POF1B | TMOD1 | ENSP00000362238 | ENSP00000259365 | Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. | Tropomodulin-1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. | 0.440 |
POF1B | TMPO | ENSP00000362238 | ENSP00000266732 | Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. | Lamina-associated polypeptide 2, isoform alpha; May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. | 0.445 |
THYN1 | LIMCH1 | ENSP00000341657 | ENSP00000425631 | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. | LIM and calponin homology domains 1. | 0.433 |
TIGD4 | LIMCH1 | ENSP00000355162 | ENSP00000425631 | Tigger transposable element derived 4. | LIM and calponin homology domains 1. | 0.490 |
TMOD1 | LIMCH1 | ENSP00000259365 | ENSP00000425631 | Tropomodulin-1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. | LIM and calponin homology domains 1. | 0.420 |