STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C16orf58RUS1 family protein C16orf58; Chromosome 16 open reading frame 58; Belongs to the RUS1 family (468 aa)    
Predicted Functional Partners:
TBC1D10B
TBC1 domain family member 10B; Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A
      
 0.688
SEPHS2
Selenide, water dikinase 2; Synthesizes selenophosphate from selenide and ATP; Selenoproteins
   
  
 0.678
OR2B2
Olfactory receptor 2B2; Odorant receptor; Olfactory receptors, family 2
      
 0.623
TAOK3
Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF)
      
 0.556
IFNGR1
Interferon gamma receptor 1; Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway; CD molecules
    
   0.551
ZSWIM2
E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes; Ring finger proteins
      
 0.548
ZSCAN12
Zinc finger and SCAN domain-containing protein 12; May be involved in transcriptional regulation; SCAN domain containing
      
 0.524
MVD
Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes
 
 
    0.504
KAZN
Kazrin; Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known; Sterile alpha motif domain containing
      
 0.497
SLC5A2
Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1; Solute carriers
   
  
 0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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