node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPM | RCN2 | ENSP00000356379 | ENSP00000319739 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | Reticulocalbin-2; Not known. Binds calcium. | 0.674 |
KDELR1 | RCN2 | ENSP00000329471 | ENSP00000319739 | ER lumen protein-retaining receptor 1; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Belongs to the ERD2 family. | Reticulocalbin-2; Not known. Binds calcium. | 0.822 |
NPTX1 | NPTX2 | ENSP00000307549 | ENSP00000265634 | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). | 0.559 |
NPTX1 | NPTXR | ENSP00000307549 | ENSP00000327545 | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | 0.655 |
NPTX1 | RCN2 | ENSP00000307549 | ENSP00000319739 | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | Reticulocalbin-2; Not known. Binds calcium. | 0.734 |
NPTX2 | NPTX1 | ENSP00000265634 | ENSP00000307549 | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | 0.559 |
NPTX2 | NPTXR | ENSP00000265634 | ENSP00000327545 | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). | Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | 0.836 |
NPTX2 | RCN2 | ENSP00000265634 | ENSP00000319739 | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). | Reticulocalbin-2; Not known. Binds calcium. | 0.762 |
NPTXR | NPTX1 | ENSP00000327545 | ENSP00000307549 | Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | 0.655 |
NPTXR | NPTX2 | ENSP00000327545 | ENSP00000265634 | Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). | 0.836 |
NPTXR | RCN2 | ENSP00000327545 | ENSP00000319739 | Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | Reticulocalbin-2; Not known. Binds calcium. | 0.928 |
PXN | RCN2 | ENSP00000267257 | ENSP00000319739 | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion); Belongs to the paxillin family. | Reticulocalbin-2; Not known. Binds calcium. | 0.544 |
RCN2 | ASPM | ENSP00000319739 | ENSP00000356379 | Reticulocalbin-2; Not known. Binds calcium. | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | 0.674 |
RCN2 | KDELR1 | ENSP00000319739 | ENSP00000329471 | Reticulocalbin-2; Not known. Binds calcium. | ER lumen protein-retaining receptor 1; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Belongs to the ERD2 family. | 0.822 |
RCN2 | NPTX1 | ENSP00000319739 | ENSP00000307549 | Reticulocalbin-2; Not known. Binds calcium. | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | 0.734 |
RCN2 | NPTX2 | ENSP00000319739 | ENSP00000265634 | Reticulocalbin-2; Not known. Binds calcium. | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). | 0.762 |
RCN2 | NPTXR | ENSP00000319739 | ENSP00000327545 | Reticulocalbin-2; Not known. Binds calcium. | Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | 0.928 |
RCN2 | PXN | ENSP00000319739 | ENSP00000267257 | Reticulocalbin-2; Not known. Binds calcium. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion); Belongs to the paxillin family. | 0.544 |
RCN2 | SFXN1 | ENSP00000319739 | ENSP00000316905 | Reticulocalbin-2; Not known. Binds calcium. | Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine. May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs to the sideroflexi [...] | 0.618 |
RCN2 | SIPA1L1 | ENSP00000319739 | ENSP00000450832 | Reticulocalbin-2; Not known. Binds calcium. | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | 0.592 |