node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CS | ENSP00000466259 | ENSP00000342056 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | 0.998 |
ACLY | ENO1 | ENSP00000466259 | ENSP00000495530 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | 0.577 |
ACLY | ENO3 | ENSP00000466259 | ENSP00000324105 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.447 |
ACLY | MDH2 | ENSP00000466259 | ENSP00000327070 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | 0.981 |
ACLY | PC | ENSP00000466259 | ENSP00000498994 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.974 |
ACLY | PCK1 | ENSP00000466259 | ENSP00000319814 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. Belongs to the phosphoenolpyruvate carboxykinase [...] | 0.959 |
ACLY | PKLR | ENSP00000466259 | ENSP00000339933 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate kinase PKLR; Plays a key role in glycolysis. | 0.586 |
ACLY | PKM | ENSP00000466259 | ENSP00000320171 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.680 |
CS | ACLY | ENSP00000342056 | ENSP00000466259 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.998 |
CS | ENO1 | ENSP00000342056 | ENSP00000495530 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | 0.620 |
CS | ENO2 | ENSP00000342056 | ENSP00000437402 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium- dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). | 0.540 |
CS | ENO3 | ENSP00000342056 | ENSP00000324105 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.513 |
CS | ENO4 | ENSP00000342056 | ENSP00000345555 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Enolase 4; May be required for sperm motility and function. | 0.440 |
CS | MDH2 | ENSP00000342056 | ENSP00000327070 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | 0.999 |
CS | PC | ENSP00000342056 | ENSP00000498994 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.987 |
CS | PCK1 | ENSP00000342056 | ENSP00000319814 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. Belongs to the phosphoenolpyruvate carboxykinase [...] | 0.955 |
CS | PKLR | ENSP00000342056 | ENSP00000339933 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Pyruvate kinase PKLR; Plays a key role in glycolysis. | 0.565 |
CS | PKM | ENSP00000342056 | ENSP00000320171 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.667 |
ENO1 | ACLY | ENSP00000495530 | ENSP00000466259 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.577 |
ENO1 | CS | ENSP00000495530 | ENSP00000342056 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Belongs to the enolase family. | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | 0.620 |