node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSA | ARSD | ENSP00000216124 | ENSP00000370546 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase D. | 0.513 |
ARSA | ARSG | ENSP00000216124 | ENSP00000407193 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | 0.924 |
ARSA | ARSH | ENSP00000216124 | ENSP00000370522 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase family member H. | 0.500 |
ARSA | ARSJ | ENSP00000216124 | ENSP00000320219 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase family member J. | 0.595 |
ARSA | ARSK | ENSP00000216124 | ENSP00000369346 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase family member K. | 0.621 |
ARSA | ARSL | ENSP00000216124 | ENSP00000500220 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Arylsulfatase L; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. | 0.498 |
ARSA | STS | ENSP00000216124 | ENSP00000217961 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | 0.517 |
ARSA | SUMF1 | ENSP00000216124 | ENSP00000272902 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.957 |
ARSA | SUMF2 | ENSP00000216124 | ENSP00000498402 | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.777 |
ARSD | ARSA | ENSP00000370546 | ENSP00000216124 | Arylsulfatase D. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.513 |
ARSD | ARSG | ENSP00000370546 | ENSP00000407193 | Arylsulfatase D. | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | 0.476 |
ARSD | ARSH | ENSP00000370546 | ENSP00000370522 | Arylsulfatase D. | Arylsulfatase family member H. | 0.426 |
ARSD | ARSJ | ENSP00000370546 | ENSP00000320219 | Arylsulfatase D. | Arylsulfatase family member J. | 0.638 |
ARSD | ARSK | ENSP00000370546 | ENSP00000369346 | Arylsulfatase D. | Arylsulfatase family member K. | 0.672 |
ARSD | ARSL | ENSP00000370546 | ENSP00000500220 | Arylsulfatase D. | Arylsulfatase L; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. | 0.552 |
ARSD | STS | ENSP00000370546 | ENSP00000217961 | Arylsulfatase D. | Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. | 0.463 |
ARSD | SUMF1 | ENSP00000370546 | ENSP00000272902 | Arylsulfatase D. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Belongs to the sulfatase-modifying factor family. | 0.701 |
ARSD | SUMF2 | ENSP00000370546 | ENSP00000498402 | Arylsulfatase D. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.670 |
ARSG | ARSA | ENSP00000407193 | ENSP00000216124 | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | Arylsulfatase A component B; Hydrolyzes cerebroside sulfate. | 0.924 |
ARSG | ARSD | ENSP00000407193 | ENSP00000370546 | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. | Arylsulfatase D. | 0.476 |