node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASTE1 | CCDC168 | ENSP00000426421 | ENSP00000320232 | Protein asteroid homolog 1; Possible role in EGF receptor signaling. | Coiled-coil domain containing 168. | 0.430 |
CCDC168 | ASTE1 | ENSP00000320232 | ENSP00000426421 | Coiled-coil domain containing 168. | Protein asteroid homolog 1; Possible role in EGF receptor signaling. | 0.430 |
CCDC168 | FBF1 | ENSP00000320232 | ENSP00000490726 | Coiled-coil domain containing 168. | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. | 0.458 |
CCDC168 | FSIP2 | ENSP00000320232 | ENSP00000401306 | Coiled-coil domain containing 168. | Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis. | 0.435 |
CCDC168 | MEAF6 | ENSP00000320232 | ENSP00000362166 | Coiled-coil domain containing 168. | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] | 0.452 |
CCDC168 | NMNAT3 | ENSP00000320232 | ENSP00000495112 | Coiled-coil domain containing 168. | Nicotinamide nucleotide adenylyltransferase 3. | 0.452 |
CCDC168 | RBM5 | ENSP00000320232 | ENSP00000343054 | Coiled-coil domain containing 168. | RNA-binding protein 5; Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby pr [...] | 0.425 |
CCDC168 | RNF223 | ENSP00000320232 | ENSP00000410533 | Coiled-coil domain containing 168. | Ring finger protein 223. | 0.488 |
CCDC168 | SLC17A9 | ENSP00000320232 | ENSP00000359376 | Coiled-coil domain containing 168. | Solute carrier family 17 member 9; Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. | 0.456 |
CCDC168 | VPS33A | ENSP00000320232 | ENSP00000267199 | Coiled-coil domain containing 168. | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.457 |
CCDC168 | ZNF563 | ENSP00000320232 | ENSP00000293725 | Coiled-coil domain containing 168. | Zinc finger protein 563; May be involved in transcriptional regulation. | 0.502 |
FBF1 | CCDC168 | ENSP00000490726 | ENSP00000320232 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. | Coiled-coil domain containing 168. | 0.458 |
FBF1 | SLC17A9 | ENSP00000490726 | ENSP00000359376 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. | Solute carrier family 17 member 9; Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. | 0.402 |
FBF1 | VPS33A | ENSP00000490726 | ENSP00000267199 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.408 |
FBF1 | ZNF563 | ENSP00000490726 | ENSP00000293725 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. | Zinc finger protein 563; May be involved in transcriptional regulation. | 0.507 |
FSIP2 | CCDC168 | ENSP00000401306 | ENSP00000320232 | Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis. | Coiled-coil domain containing 168. | 0.435 |
MEAF6 | CCDC168 | ENSP00000362166 | ENSP00000320232 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] | Coiled-coil domain containing 168. | 0.452 |
MEAF6 | RNF223 | ENSP00000362166 | ENSP00000410533 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] | Ring finger protein 223. | 0.518 |
NMNAT3 | CCDC168 | ENSP00000495112 | ENSP00000320232 | Nicotinamide nucleotide adenylyltransferase 3. | Coiled-coil domain containing 168. | 0.452 |
NMNAT3 | SLC17A9 | ENSP00000495112 | ENSP00000359376 | Nicotinamide nucleotide adenylyltransferase 3. | Solute carrier family 17 member 9; Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. | 0.400 |