STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRRC75BLeucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. (315 aa)    
Predicted Functional Partners:
C22orf15
Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15.
      
 0.718
GUCD1
Protein GUCD1; Guanylyl cyclase domain containing 1.
 
    
 0.652
DRICH1
Aspartate-rich protein 1; Aspartate rich 1.
   
  
 0.622
PROSER2
Proline and serine rich 2.
      
 0.581
ZNF70
Zinc finger protein 70; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.571
GSTT4
Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.
      
 0.567
DDTL
D-dopachrome decarboxylase-like protein; May have lyase activity; Belongs to the MIF family.
      
 0.542
RGL4
Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4.
      
 0.507
STOML1
Stomatin-like protein 1; May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation ; Belongs to the band 7/mec-2 family.
   
  
 0.449
SPECC1L
Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
      
 0.434
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.