| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APPBP2 | CCDC89 | ENSP00000083182 | ENSP00000320649 | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | 0.479 |
| APPBP2 | DCAF12 | ENSP00000083182 | ENSP00000355114 | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | 0.587 |
| CCDC89 | APPBP2 | ENSP00000320649 | ENSP00000083182 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. | 0.479 |
| CCDC89 | CEP44 | ENSP00000320649 | ENSP00000389427 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Centrosomal protein 44. | 0.554 |
| CCDC89 | DCAF12 | ENSP00000320649 | ENSP00000355114 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | 0.482 |
| CCDC89 | KIF14 | ENSP00000320649 | ENSP00000356319 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | 0.650 |
| CCDC89 | KIF20B | ENSP00000320649 | ENSP00000360793 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Kinesin-like protein KIF20B; Plus-end-directed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage [...] | 0.581 |
| CCDC89 | KLHL15 | ENSP00000320649 | ENSP00000332791 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through e [...] | 0.499 |
| CCDC89 | KNSTRN | ENSP00000320649 | ENSP00000249776 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Small kinetochore-associated protein; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule [...] | 0.508 |
| CCDC89 | LRRC45 | ENSP00000320649 | ENSP00000306760 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | 0.607 |
| CCDC89 | NECAB1 | ENSP00000320649 | ENSP00000387380 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | N-terminal EF-hand calcium binding protein 1. | 0.491 |
| CCDC89 | SPAG6 | ENSP00000320649 | ENSP00000365811 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.491 |
| CEP44 | CCDC89 | ENSP00000389427 | ENSP00000320649 | Centrosomal protein 44. | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | 0.554 |
| CEP44 | LRRC45 | ENSP00000389427 | ENSP00000306760 | Centrosomal protein 44. | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. | 0.573 |
| DCAF12 | APPBP2 | ENSP00000355114 | ENSP00000083182 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. | 0.587 |
| DCAF12 | CCDC89 | ENSP00000355114 | ENSP00000320649 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | 0.482 |
| KIF14 | CCDC89 | ENSP00000356319 | ENSP00000320649 | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | 0.650 |
| KIF14 | KIF20B | ENSP00000356319 | ENSP00000360793 | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | Kinesin-like protein KIF20B; Plus-end-directed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage [...] | 0.946 |
| KIF14 | KNSTRN | ENSP00000356319 | ENSP00000249776 | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | Small kinetochore-associated protein; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule [...] | 0.603 |
| KIF20B | CCDC89 | ENSP00000360793 | ENSP00000320649 | Kinesin-like protein KIF20B; Plus-end-directed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage [...] | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | 0.581 |
