STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USF3Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. (2245 aa)    
Predicted Functional Partners:
TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
  
    0.606
ASTE1
Protein asteroid homolog 1; Possible role in EGF receptor signaling.
   
 
 0.543
ANKAR
Ankyrin and armadillo repeat containing.
   
 
 0.480
ADNP2
Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation.
  
    0.461
ZNF236
Zinc finger protein 236; May be involved in transcriptional regulation.
   
 
 0.457
CAPN12
Calpain-12; Calcium-regulated non-lysosomal thiol-protease.
    
 
 0.455
CCDC150
Coiled-coil domain containing 150.
      
 0.455
TCF20
Transcription factor 20; Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
  
 
 0.449
TMEM244
Transmembrane protein 244.
      
 0.447
MRPL34
Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family.
    
 
 0.432
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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