node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD49 | TRIT1 | ENSP00000440396 | ENSP00000321810 | Ankyrin repeat domain-containing protein 49; Induces HBG1 expression. May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway (By similarity). | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.925 |
CDK5RAP1 | GTPBP3 | ENSP00000217372 | ENSP00000351644 | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | 0.658 |
CDK5RAP1 | GTPBP6 | ENSP00000217372 | ENSP00000316598 | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | GTP binding protein 6. | 0.417 |
CDK5RAP1 | MRM2 | ENSP00000217372 | ENSP00000242257 | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. | 0.427 |
CDK5RAP1 | TRIT1 | ENSP00000217372 | ENSP00000321810 | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.787 |
CDK5RAP1 | TRMT5 | ENSP00000217372 | ENSP00000261249 | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. | 0.503 |
CDK5RAP1 | TRMU | ENSP00000217372 | ENSP00000496496 | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Belongs to the MnmA/TRMU family. | 0.656 |
FTSJ1 | TRIT1 | ENSP00000326948 | ENSP00000321810 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.846 |
FTSJ1 | TRMT5 | ENSP00000326948 | ENSP00000261249 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily. | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. | 0.757 |
FTSJ3 | MRM2 | ENSP00000396673 | ENSP00000242257 | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. | 0.409 |
FTSJ3 | TRIT1 | ENSP00000396673 | ENSP00000321810 | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.747 |
FTSJ3 | TRMT5 | ENSP00000396673 | ENSP00000261249 | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. | 0.528 |
GTPBP3 | CDK5RAP1 | ENSP00000351644 | ENSP00000217372 | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | 0.658 |
GTPBP3 | GTPBP6 | ENSP00000351644 | ENSP00000316598 | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | GTP binding protein 6. | 0.494 |
GTPBP3 | MRM2 | ENSP00000351644 | ENSP00000242257 | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. | 0.478 |
GTPBP3 | TRIT1 | ENSP00000351644 | ENSP00000321810 | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.755 |
GTPBP3 | TRMT5 | ENSP00000351644 | ENSP00000261249 | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. | 0.565 |
GTPBP3 | TRMU | ENSP00000351644 | ENSP00000496496 | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Belongs to the MnmA/TRMU family. | 0.975 |
GTPBP6 | CDK5RAP1 | ENSP00000316598 | ENSP00000217372 | GTP binding protein 6. | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily. | 0.417 |
GTPBP6 | GTPBP3 | ENSP00000316598 | ENSP00000351644 | GTP binding protein 6. | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. | 0.494 |