TUFM protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TUFM

Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (455 aa)

Predicted Functional Partners:

TSFM

0.999

MRPS16

0.999

MRPL17

0.997

MRPL33

0.997

MRPL12

0.997

MRPL20

0.997

MRPL32

0.996

MRPL36

0.996

MRPL21

0.995

MRPL9

0.995

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MRPL12	MRPL17	ENSP00000333837	ENSP00000288937	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein L17.	0.998
MRPL12	MRPL20	ENSP00000333837	ENSP00000341082	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein L20.	0.998
MRPL12	MRPL21	ENSP00000333837	ENSP00000354580	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein L21.	0.996
MRPL12	MRPL32	ENSP00000333837	ENSP00000223324	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.	0.999
MRPL12	MRPL33	ENSP00000333837	ENSP00000296102	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein L33.	0.998
MRPL12	MRPL36	ENSP00000333837	ENSP00000423399	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	0.997
MRPL12	MRPL9	ENSP00000333837	ENSP00000357823	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein L9.	0.999
MRPL12	MRPS16	ENSP00000333837	ENSP00000362036	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.	0.997
MRPL12	TSFM	ENSP00000333837	ENSP00000313877	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.953
MRPL12	TUFM	ENSP00000333837	ENSP00000322439	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.997
MRPL17	MRPL12	ENSP00000288937	ENSP00000333837	Mitochondrial ribosomal protein L17.	39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.	0.998
MRPL17	MRPL20	ENSP00000288937	ENSP00000341082	Mitochondrial ribosomal protein L17.	Mitochondrial ribosomal protein L20.	0.998
MRPL17	MRPL21	ENSP00000288937	ENSP00000354580	Mitochondrial ribosomal protein L17.	Mitochondrial ribosomal protein L21.	0.998
MRPL17	MRPL32	ENSP00000288937	ENSP00000223324	Mitochondrial ribosomal protein L17.	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.	0.999
MRPL17	MRPL33	ENSP00000288937	ENSP00000296102	Mitochondrial ribosomal protein L17.	Mitochondrial ribosomal protein L33.	0.998
MRPL17	MRPL36	ENSP00000288937	ENSP00000423399	Mitochondrial ribosomal protein L17.	Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.	0.998
MRPL17	MRPL9	ENSP00000288937	ENSP00000357823	Mitochondrial ribosomal protein L17.	Mitochondrial ribosomal protein L9.	0.998
MRPL17	MRPS16	ENSP00000288937	ENSP00000362036	Mitochondrial ribosomal protein L17.	Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.	0.998
MRPL17	TSFM	ENSP00000288937	ENSP00000313877	Mitochondrial ribosomal protein L17.	Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.938
MRPL17	TUFM	ENSP00000288937	ENSP00000322439	Mitochondrial ribosomal protein L17.	Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.997

page 1 of 6

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About